Cervical cancer is one of the leading causes of cancer related deaths among Indian women. One of the major risk factors, which accounts for 99.7%, cases of the cervical cancer is persistent infection with a sexually transmitted, high risk Human Papilloma Virus (HPV). It has been found that E6 and E7, two oncoproteins encoded by HPV, deregulates p53 and pRb and promotes cervical cancer in the
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Cervical cancer is one of the leading causes of cancer related deaths among Indian women. Persistent infection with oncogenic Human Papillomavirus (HPV) is the major etiology of the disease. Expression of the viral oncoproteins E6 and E7 are critical for malignant transformation of the host cells and is mediated through the interaction with other host encoded molecules. E6 regulates the deca
Read MoreOral cancer is one of the most prevalent cancers worldwide and ranks second in incidence and mortality in India. Cancer cells adopt dramatic metabolic phenotype changes to acquire sufficient nutrients to support proliferation, cell growth, immune response, and redox homeostasis. My research interest is to understand the regulation of such metabolic remodelling that facilitates metabolic phenotype
Read MoreGlobally, 25% of children < 5years suffer from growth restriction and impairment of overall development. India represents one-third of the global burden (38.4% born annually). Despite its high prevalence, biological and other associated factors that can lead to this condition are poorly understood. My research interest is focused on studying the impact of breastfeeding practices in the change i
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Tuberculosis (TB) is primarily an infection of the lungs caused by Mycobacterium tuberculosis complex (MTBC). This complex comprises of upto seven Mycobacterium species including but not limited to Mycobacterium tuberculosis (M.tb) and M. bovis. This disease is a major public health burden for the country with India accounting for 27% of the world TB cases. This strain on the health
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The overarching goal of my research is to study the ancestry of Indian populations, mainly the Ancestral South Indians (ASI) and the admixture of ASI with other populations. The early migration and ancestries of Indian populations are hugely debated and there is a lack of consensus on important issues. I will use advanced statistical methods, simulation studies and genomic data to gain furt
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JMJD6 has diverse enzymatic activities including histone arginine demethylation, lysyl hydroxylation, and is recently shown to phosphorylate proteins. It’s high expression is robustly associated with poor prognosis in breast cancer. JMJD6 binds RNA but lacks a DNA binding domain. However, by interacting with other transcription factors like BRD4, it was recently shown to regulate the anti
Read MoreSquamous cell carcinoma of the oral cavity accounts for the top-most cancer-related mortality among men and sixth-most among women in India (GLOBOCAN-2020) due to rampant tobacco usage. Majority of oral cancer is detected at an advanced stage contributing to frequent treatment failure (recurrence, metastasis etc.) and poor disease-free-prognosis of the patient. Our recent multi-omics study (Ghosh
Read MoreOral squamous cell carcinoma (OSCC) is a major cancer type globally and the most common form of cancer in men in India. Oral submucous fibrosis (OSMF) is one of the most prevalent chronic, disabling condition of the oral mucosa and 7-30% of OSMF cases can lead to malignancy in the oral cavity. The transition from pre-malignant lesions and disorders to OSCC is a continuous process of genetic an
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Chronic pancreatitis (CP) is an irreversible disease characterized by progressive inflammation, fibrosis of pancreas, and loss of pancreatic functions. Epidemiological studies have identified CP to be a major risk factor for pancreatic ductal adenocarcinoma (PDAC). PDAC is one of the most lethal diseases with an incidence rate almost equal to the rate of mortality. Elucidation of the molecul
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