PhD Students

of heterogeneous cell types which have diverse morphologies and dynamic functions at different time points during pregnancy. My aim is to study the variations in these cell type diversity and materno-fetal interactions at different periods of gestation at delivery using single cell transcriptomic approaches. Ultimately, I would like to identify single cell gene expression signatures which are associated with adverse outcomes. Such information can be used to triage women at risk of these birth outcomes so that appropriate clinical interventions can be used. Read less

rk communication in central nervous system, providing trophic support to neurons and forming conduits for synaptic informational processing, increased Cx43 hemichannel activity leads to excitotoxicity. Interestingly, Aβ, the bonafide player of AD triggers Cx43 internalization in astrocytes with concomitant loss of gap junctional activity and increase in hemichannel activity. At this juncture, our study is directed towards understanding the Aβ-mediated astrocytic dysfunction process through gaining profound insights into the mechanistic underpinnings of Aβ mediated dysregulation of Cx43 gap junctional functions and how it contributes to AD neuropathology. Read less

n already established that some genes have role in cancer progression by using multiple pathways. some genes are identified which are affecting the cell cycle regulation, cell adhesion and organization of cytoskeleton, metastasis rate etc. I am investigating the role of one of the genes which has a role in cancer progression and I am also interested to identifying its interacting partners that helps in pancreatic cancer progression. Read less

ted expression of lncRNA as they reportedly regulate gene transcription and post transcriptional processes. We have identified lncRNAs with unknown function in our lab. My goal is to prioritize these lncRNA for functional studies by using different bioinformatics-based screening processes. To achieve this, we screened that lncRNAs on the basis of cancer relevant attributes like effect of that lncRNA on survival analysis, gene expression on normal & tumor tissues, genomic related information and prediction of RNA/protein interacting partners etc. by different web-based tools. After shortlisting lncRNAs we will try to evaluate their biological function in cancer. Read less

is found to be elevated in active TB patients. The effect of elevated CXCL10 on immune cells is not well studied. My aim of research is to explore the role of CXCL10 in alteration of downstream signaling pathways involved in host defense mechanism in context of TB using high throughput genomic tools. I am also interested to understand the influence of the chemokine in the immunological processes with advent of M.tb infection. These approaches will help us in better understanding of potential regulatory role of CXCL10 for tuberculosis disease progression.

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dant and useful than other circulatory biomarkers like Circulating tumor cells and cell-free DNAs. They can act as mediators of intracellular communication and also can promote metastasis by contributing to the formation of pre-metastatic niche. My research goal is to study the proteome of these tiny little particles from tumor tissue and serum of the breast cancer patients and compare them by proteomic profiling. Read less

of the genetic variants within the body of IFNL4 are important in generation of these splice variants.

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ccurate diagnosis.  My research therefore focuses on investigating the genomic signatures causal to CMD and CM in Indian patients. I analyse whole exome sequence data using variant calling and stringent variant filtration process to identify pathogenic mutations and achieve a genetic diagnosis.
I'm also interested in functionally characterizing the candidate variants in an in vivo zebrafish model and do a mechanistic evaluation in primary muscle cells using the efficient CRISPR-Cas genome editing tools.

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m. The missing heritability can probably be explained by other external factors. Skin is the largest organ of human body harbouring trillions of microorganisms that performs important functions. Studies have shown imbalance in microbiome (dysbiosis) to be associated with several chronic inflammatory diseases. However, how does the host genome modulate the composition and diversity of the resident skin microbiome is not well known. My research interest is focused on investigating the specific host-microbiome interactions which can explain the complex etiology of AD as well as mechanistic in vitro host cell-microbial co-culture experiments which might lead to cues for future therapeutic approaches. Read less

ed to tobacco chewing and smoking habits. Few driver genes were recently identified for late-stage OSCC-GB from genome-scale studies. Identification of early stage OSCC-GB biomarkers is of extreme importance, because it might potentially lead to precise understanding of the molecular mechanisms of tumor initiation, as well as the factors whose alteration might lead to progression of tumor. My research objective is to leverage state-of-the-art genomic technologies for understanding the profile of the genomic drivers of early stage OSCC-GB tumors. Deeper understanding of the molecular underpinnings of the alterations of these drivers will provide improved diagnosis, more precise risk prediction as well as better response to therapy.

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