Human disease genomics and platform technologies
Palodhi A, Ghosh S, Biswas NK, Basu A, Majumder PP, Maitra A*. Profiling of genomic alterations of mitochondrial DNA in gingivobuccal oral squamous cell carcinoma: Implications for disease progress. Mitochondrion. 2018 Sep 24.pii: S1567-7249(18)30030-8.
Sundar S, Khetrapal-Singh P, Frampton J, Trimble E, Rajaraman P, Mehrotra R, Hariprasad R, Maitra A, Gill P, Suri V, Srinivasan R. Harnessing genomics to improve outcomes for women with cancer in India: key priorities for research. The Lancet Oncology. 2018 Feb 28;19(2):e102-12.
India Project Team of the International Cancer Genome Consortium. Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nat Commun. 2013;4:2873.
Maitra A*, Dash D, John S, Sannappa PR, Das AP, Shanker J, Rao VS, Sridhara H, Kakkar VV. A common variant in chromosome 9p21 associated with coronary artery disease in Asian Indians. J Genet. 2009 Apr;88(1):113-8.
Maitra A*, Shanker J, Dash D, John S, Sannappa PR, Rao VS, Ramanna JK, Kakkar VV. Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease--the Indian Atherosclerosis Research Study. Thromb Haemost. 2008 May;99(5):944-50. Editorial Comment in: Thromb Haemost 2008;99:991-992.
*Corresponding Author
The “Genomics and Global Health Report 2004” has identified genomics as “the powerful new wave of health-related life sciences” with tremendous potential to address unresolved health problems, especially in the developing countries. My research mission is to rise to this challenge by harnessing emerging genomics technologies to uncover important and novel information on human health and disease. The emergence of techniques like massively parallel DNA sequencing methods (MPS) has revolutionized our ability to identify causal genomic variants in various human health conditions. Exome and whole genome sequencing based approaches have already been shown to be successful in uncovering the genetic basis of multiple diseases. My aim is to harness emerging technologies like MPS to identify the genetic basis of causality of diseases with special emphasis on maternal and infant health (preterm birth) and cancer. The ultimate purpose of undertaking such work is to discover important genetic information which can be translated into the identification of actionable targets to reduce the public health burden.
I believe in the emanation of scientific knowledge for capacity building in research, in building a partnership with the industry and in engaging with the community at large. Hence, my activities and future plans are geared toward the realization of these goals. I actively participate in the teaching activities and workshops that are hosted for students and clinicians. I also participate in various programs with the industry and in the community programs undertaken by the institute to engage with the general population on biomedical genomics.
Projects: (extramurally funded)
Maternal & Infant Health:
Project Coordinator & Principal Investigator. Grand Challenge India Grant (DBT, Bill & Melinda Gates Foundation, BIRAC & USAID): “Stress outcomes on pregnancy, fetal growth and birth weight Development of methods to identify mothers at risk of preterm birth and intrauterine growth restriction resulting from maternal stress.” Collaborators: Dr. Nitya Wadhwa, Pediatric Biology Center, Translational Health Science & Technology Institute (THSTI) & Dr. Tushar Kanti Maiti, Regional Centre for Biotechnology, Faridabad.
Co – investigator. Grand Challenge Program (DBT): “Inter-institutional program for Maternal, Neonatal and Infant Sciences – A translational approach to studying Preterm Birth.” Principal Investigator (NIBMG): Professor Partha Pratim Majumder. Project Coordinator and Principal Investigator (THSTI): Professor Shinjini Bhatnagar. Collaborators: THSTI, RCB, Civil Hospital Gurgaon, Safderjung Hospital, AIIMS, MAMC.
Co – investigator. Research & Development Grant (DBT): “Molecular Basis of Nutrient Mediated Fetal Programming of Diabesity.” Principal Investigator (NIBMG): Professor Partha Pratim Majumder. Team Leader and Principal Investigator (KEMHRC): Professor Chittaranjan S Yajnik. Collaborators: KEHMRC, CCMB, IISER – Pune, IISc.
Co – investigator. Research & Development Grant (DBT West Bengal Govt.) “A Pilot Study on the Role of Gut Microbiome in Gestational Diabetes Mellitus.” Collaborator: Professor Subhankar Chowdhury, IPGMER.
Cancer Genomics:
Co-Principal Investigator. DBT Twinning Project: “Identification of Biomarkers of Oropharyngeal Cancer Prevalent in North-Eastern State of India by Whole Genome Methylation and Expression Profiling.” Principal Investigator: Collaborators: Professor Partha Pratim Majumder (NIBMG), Professor Sharmila Sengupta (NIBMG), Dr. Srimoyee Ghosh (NEHU), Dr. Briyan N. Shunyu (NEIGRIHMS).
Co-Principal Investigator. DBT Twinning Project: “Identification of recurrent somatic mutations in Gastric Adenocarcinoma in Mizo population, Northeast India.” Principal Investigator: Collaborators: Dr. Arindam Maitra (NIBMG), Dr. N. Senthil Kumar (Mizoram University, Aizawl, Mizoram), Dr Jeremy L. Pautu (Mizoram State Cancer Institute), Dr John Zomingthanga (Civil Hospital Aizawl, Mizoram).
Training:
Co-Principal Investigator. DBT NER – BPMC Training Grant: “Enhancing capacity in genomics-driven research in human health & disease in the north-east region.” Principal Investigator: Professor Sharmila Sengupta.
Year | Degree | University |
---|---|---|
1999 | Ph.D | All India Institute of Medical Sciences (AIIMS), New Delhi |
1993 | M.Sc | University College of Science, University of Calcutta, Kolkata |
1991 | B.Sc | Presidency College, University of Calcutta, Kolkata |
2012 - Till Date |
Associate Professor, National Institute of Biomedical Genomics (NIBMG), Kalyani Project Coordinator (NIBMG), International Cancer Genome Consortium (ICGC) – India Project Authorized Signatory, Core Technologies Research Initiative (CoTeRI) |
2009 - 2012 |
Project Manager, International Cancer Genome Consortium – India Project, National Institute of Biomedical Genomics (NIBMG), Kalyani |
2009 - 2010 |
Academic Consultant, Thrombosis Research Institute (TRI), Bangalore |
2006 - 2009 |
Section Head, Mary & Garry Weston Functional Genomics Unit, Thrombosis Research Institute (TRI), Bangalore |
2004 - 2006 |
Group Leader, The Centre for Genomic Application (TCGA), New Delhi |
2004 - 2006 |
Honorary Consultant (DNA Technologies), Directorate of Forensic Science, Ministry of Home Affairs, Govt. of India, New Delhi |
1999 - 2004 |
Technical Support Specialist & Member, European Task Forces on high throughput electrophoresis, gene expression, genotyping and forensic DNA analysis in Applied Biosystems (ABI), New Delhi |
Life Member, Society of Biological Chemists (SBC), India
Life Member, The Indian Society of Human Genetics (ISHG)
Life Member, Calcutta Consortium of Human Genetics (CCHuGe)
Year |
Award |
---|---|
2015 |
Guest lecturer of Department of Biochemistry, University of Calcutta |
2009 |
International travel grant, Department of Science & Technology (DST), Govt. of India for participation in XXII Annual Congress of International Society on Thrombosis and Haemostasis (ISTH), Boston |
2008-Present |
Invited reviewer of international journals Scientific Reports, PLOS One, Atherosclerosis, Thrombosis and Haemostasis, BMC Cardiovascular Disorders, Diabetes Research and Clinical Practice, Journal of Translational Medicine, Journal of Genetics, Journal of Biosciences, Genes and Genetic Systems, Saudi Medical Journal |
2008 |
Invited author of research commentary entitled “Interleukin-6 Gene Polymorphisms Associated with CAD in Asian Indians: Implication of Genetic Markers of Premature Disease Onset” in e-newsletter of International Atherosclerosis Society |
1999 |
International travel grant, Council for Scientific & Industrial Research (CSIR), Govt. of India for participation in 6th International Annual Discussion Meeting on HIV Dynamics and Evolution, Atlanta |
1998 |
Takashi Kurimura Award for the best paper on HIV research, First International Conference on AIDS INDIA 2000, Chennai |
1993 |
CSIR fellowship, National Eligibility Test (NET), India |
Year |
Institute/meeting, Title of the talk |
---|---|
2016 |
PGIMER, Next Generation Sequencing in the Workshop of 5th Annual Conference of the Molecular Pathology Association of India (MPAI) and International Symposium Integration of Genetics and Genomics in Laboratory Medicine, “Methods of Next Generation Sequencing” and “Targeted Resequencing” NIBMG, NIBMG – University of Chicago Workshop on Big Data Analysis in BioMedical Genomics, “Introduction to high throughput genomic platforms” Vision Research Foundation, 41st Annual Meeting and International Conference of the Indian Society of Human Genetics (ISHG), "Next Generation Cancer Genomics - The International Cancer Genome Consortium India Project" |
2015 |
North Eastern Hill University, Symposium Lecture at the “International Conference on Molecular Signalling: Recent Trends in Biosciences, “Next Generation Cancer Genomics – The ICGC Project” Bill & Melinda Gates Foundation, 2015 Grand Challenges, “Stress outcomes on pregnancy, fetal growth and birth weight Development of methods to identify mothers at risk of preterm birth and intrauterine growth restriction resulting from maternal stress” Lady Brabourne College, Faculty Improvement Program, “Next Generation Cancer Genomics” Institute of Cytology and Preventive Oncology (ICMR), Brainstorming Meeting on Base-pair to Bedside: Genomics and Cancer Prevention, “Next Generation Cancer Genomics - Our Experiences in the ICGC Project” University of Chicago Delhi Center, India – UChicago Cancer Workshop, “Genomics and epigenomics of oral cancer” NIBMG, NIBMG Winter School on Analysis of Massively Parallel Sequencing (NGS) Data, “Introduction to NGS Technology: Methods and Applications” and “Targeted Resequencing” National Institute of Immunohaematology, 40th Annual Meeting and International Conference of the Indian Society of Human Genetics (ISHG), “Next Generation Human Genetics: Opportunities and Challenges” |
2014 |
NIBMG, NIBMG Winter School on From GWAS Hits to Targeted Resequencing, “Targeted Resequencing: Startegies and Methods” and “Designing Resequencing Assays” Center for liver Disease, IPGMER, Calcutta Consortium of Human Genetics (CCHuGe) Symposium on Next Generation Sequencing and its applications in human genetics and disease, “Technologies and Applications of NGS in Human Genetics” |
2013 |
CSIR – Institute of Genomics and Integrative Biology (IGIB), Genomeet Workshop on Next Generation Sequencing: Technology, Applications and Data Analysis, “Application of Next Generation Sequencing in Cancer Genomics” International Centre for Genetic Engineering and Biotechnology (ICGEB) New Delhi, Applications of Bioinformatics in Modern Molecular Biology, “Introduction to Massively Parallel Sequencing” and “Next Generation Human Genetics - The New Wave in Disease Research” Life Technologies Innovation Update Series, Chennai, “Targeted Sequencing Approach for Next Generation Human Genetics” Centre for Cellular and Molecular Platforms (C-CAMP), “Next Generation Human Genetics: The New Wave in Disease Research” Cancer Informatics Workshop, ACTREC, “An introduction to human exome sequencing” NIBMG, NIBMG-EBI Winter School on Analysis of Massively Parallel Sequencing Data, NIBMG, “Introduction to Next Generation Sequencing Technologies and Applications” |
2012 |
Symposium on Roche-45 Sequencing Approach – Metagenomic Study of Coastal Microbial Diversity, Department of Biochemistry, University of Calcutta, “My Experiences with GS FLX DNA Sequencing” |
2012 |
Workshop for research scholars of the DBT-IPLS Departments of University of Calcutta on Introduction to Next Generation Sequencing: Learning the Platforms and Basics of NGS Data Analysis, NIBMG, “Next Generation DNA Sequencing: Introduction, Workflow and Applications” |
2012 |
Roche Sequencing APAC User Conference, Bangkok, “Exome Sequencing Analysis of Gingivobuccal Cancer: The International Cancer Genome Consortium-India Project” |
2011 |
International Conference on Omics meet Diseases, SINP, “Exome Sequencing of Gingivobuccal Cancer in International Cancer Genome Consortium-Indian Initiative” |
2011 |
Indian Association for Cultivation of Science, Kolkata, “Decoding the cancer genome in the next gen era: the ICGC initiative” |
2011 |
National Workshop on Biostatistics: Applications of Computational Statistics in Medicine and Biology, IIT Kharagpur, . “Exome Sequencing Analysis in International Cancer Genome Consortium-Indian Initiative” |
2011 |
Next Generation Sequence (NGS) Data Analysis Workshop, IBAB, “Cancer Genome Sequencing” |
2011 |
Ist Regional Workshop on Sequencing Experimental Design and Quantitative Genomics, University of Delhi South Campus, : “Exome Resequencing: Next Gen Tool for Disease Genetics” |
2011 |
NIBMG-Welcome Trust Winter School on Genetic Dissection of Complex Disease: Analytical Approaches, NIBMG, “Introduction to Massively Parallel DNA Sequencing” |
2010 |
Workshop on Clinical and Genetic Aspects of Chronic and Infectious Disease With Special Reference to Cancer and Tuberculosis, NIBMG, “International Cancer Genome Consortium-India Project: An Overview” |
2010 |
Workshop on Introduction to Human Genetics and Genomics, NIBMG, “Genetics of Cardiovascular Disease” |
2010 |
Workshop on Introduction to Human Genetics and Genomics, NIBMG, “DNA Amplification and Genotyping” |
2010 |
Workshop on Introduction to Human Genetics and Genomics, NIBMG, “DNA Sequencing” |
2010 |
Science Camp for High School Students by Jagadis Bose National Science Talent Search, NIBMG, “Introduction to Cancer Genetics” |
2009 |
XXII Annual Congress of International Society on Thrombosis and Haemostasis (ISTH), “Interleukin-6 gene polymorphisms in Asian Indian families with premature coronary artery disease” |
2005 |
Workshop on Diagnosis of Genetic Disorders Using Cytogenetics and Molecular Genetics Methods, AIIMS, “Microarray in the Era of Genomics and Proteomics” |
2004 |
Workshop on DNA Markers: Development and Applications, 8th ADNAT Convention, CCMB, “SNP Detection by TaqMan Allelic Discrimination Assays” |
2004 |
Workshop on DNA Markers: Development and Applications, 8th ADNAT Convention, CCMB, “High Throughput Sequencing for SNP Discovery” |
2003 |
Workshop on Prenatal & Postnatal Diagnosis of Genetic Disorders Using Molecular Methods, AIIMS, “Diagnosis of Genetic Disorders by Real Time PCR” |
2002 |
Workshop on Prenatal & Postnatal Diagnosis of Genetic Disorders Using Molecular Methods, AIIMS, “PCR and its Application and Troubleshooting” |
2001 |
AIIMS Symposium on HIV Vaccine Development in the XXV National Congress of Indian Association of Medical Microbiologists, “Genomic Diversity of HIV-1 Isolates from India” |
2001 |
WHO Workshop on Frontiers of Cancer Genetics, Department of Anatomy & Genetics, AIIMS, “Automated DNA Sequencing Technology” |
Principal Investigator of five-year Department of Biotechnology (Govt. of India) program grant on “Identification of Genetic Risk Factors of Premature Cardiovascular Disease in the Asian Indian Population.”
Co-investigator of Department of Biotechnology (Govt. of India) research project entitled “Genome wide linkage study in families affected with early onset coronary artery disease in the Indian population.”
Arindam Palodhi