The Institute is now operating from a huge 30-acre green campus with academic blocks, student and faculty housing and guest houses.
Laboratories, equipment (including flow-cell sequencers, whole-genome genotyping and gene expression platforms, multiplex suspension array platform, high-end computing platforms,FACS Aria-FUSION etc.), bio-banking facility, state-of-the-art tissue culture facilities and stem cell laboratory, office space and class rooms have been established.
The rapidly expanding Biorepository Platform of NIBMG provides centralized storage and preservation of all biospecimens collected from disease-specific and population-based study participants with informed voluntary consent. The preserved samples consist of blood, plasma, serum, tissues, cell scrapes, DNA, RNA and protein extracts. These are stored at temperatures ranging from -86⁰C to 4⁰C, as per requirement, for current and future use by researchers of NIBMG as well as those working in collaboration with the institute.
The high performance computing and centralized data storage services of NIBMG are operated on 24x7 mode from a Data Centre located inside the institute. The facility consists of the following components:
NIBMG has specialized computational labs for diverse data analysis requirements of various research activities of the institute. Additionally, special facilities have been established for organizing hands on training courses and workshops on data analysis methods.
The institute has a centrally located Digital Library for accessing online Journals, e-books etc. Access to a large number of high impact scientific journals is provided by the Library through the DBT-Electronic Library Consortium (DeLCON) network.
The zebrafish is a fresh-water vertebrate that has now become well established as a model for studying vertebrate development, evolution, genetics, and cell biology, due to its small size, high fecundity and transparent embryos. Its amenability for large scale forward genetic screens, morpholino mediated knock-down of gene activity, targeted mutations and knock-in with the CRISPR/Cas9 technology and ease of transgenesis makes it an ideal vertebrate system for experimental investigations. In addition, the zebrafish is significantly more economical to house and breed compared to the mouse and most importantly, its genome is fully sequenced and highly like mammalian and human genomes. This makes the zebrafish a versatile vertebrate for the systematic modeling human diseases that range from metabolic and infectious diseases to cancer and rare Mendelian disorders.
In NIBMG, we have established a zebrafish facility that primarily intends to utilize existing expertise within our institution in disease modelling, bioinformatics, zebrafish assay development and mechanistic studies. These studies will set the stage for investigating gene networks elemental in prevailing human disease phenotypes at a functional level, and create high-throughput biology in the zebrafish as a platform to complement genome-wide association studies (GWAS) across a wide spectrum of traits. Most importantly, this approach can instantly be implemented to drug response phenotypes and novel traits as they originate. Human genomic research has already detected a substantial number of loci associated with numerous common complex human diseases and have surpassed conventional experimental methodologies for understanding intrinsic disease mechanisms. Nowadays, multiple studies worldwide have established the benefit of the zebrafish model system in investigating functionally relevant genes at GWAS loci, and in comprehending the molecular mechanisms by which these genes influence human traits. The NIBMG zebrafish facility, therefore, provides support to researchers with broader classes of genomic variations. The major function of this resource includes confirming the functionality of genes and regulatory elements underlying human disease biology with high efficiency and generation of relevant animal models that uphold in-depth studies of disease mechanisms or potential drug discovery.
Mass resolution: 200000 FWHM at approximately m/z 200 and 35000 FWHM at m/z 1000
Mass Range: Up to 6000 Da
Sensitivity: fg for standard and with S/N ratio less than 100:1 in MS/MS mode
|BD FACS Aria Fusion||UV/Violet, Blue, Red, Yellow||2 UV, 6 Violet, 3 Blue, 4 Yellow/Green, 2 Red||Assisted Sorter|
|BD Accuri SORP||Near UV, Blue||4 detectors||Non-assisted Analyzer|
Scanner: Resonant scanning head
Frame Rate: Up to 30 frame per second at 512x512 resolution
Detector: 2 PMT and 2 GaAsP detectors
Applications: High speed, time-lapse live cell confocal imaging