PhD Students

  • Esha Bhattacharjee

    Esha BhattacharjeeSupervisor: ARINDAM MAITRA

    Brief Description of Project

    Period of gestation being an important determinant of infant’s health, adverse live birth outcomes are major public health concerns of global importance.Complications from preterm birth, which is defined as any live birth before 37 completed weeks of gestation, is the leading cause of mortality of children below 5 years. Interplay between environment and underlying genomics of both the mot

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    her and the fetus results in the preterm birth outcome. To combat the global health burden, early detection of the women having higher risk for delivering preterm is highly crucial which will help to provide personalized medical care to them. Since genomic markers have the potential to identify the high-risk women even to prior to pregnancy, so I intend to study the maternal genetic influences on preterm birth.

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  • Indrani Ray

    Indrani RaySupervisor: SRIKANTA GOSWAMI

    Brief Description of Project

    Research in the last decade has shown that the genetic background for pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic tumours. PDAC has poor prognosis and a rising incidence rate. Late detection and threatening nature are two major causes for treatment failure. In case of treatment, identification of some biomarker molecules

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    helps in proper diagnosis. It has been found that some specific genes accelerate cancer progression rate in multiple pathways. There are some specific genes which act as biomarkers, affecting cell cycle regulation, cell signalling mechanisms etc. My research goal is the functional characterization of specified genes which act as progression biomarker and their interaction with other molecules that help retaining cellular proliferation in pancreatic cancer.

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  • Jagyashila Das

    Jagyashila DasSupervisor: ARINDAM MAITRA

    Brief Description of Project

    Birth outcome is an important determinant of an infant’s survival and health even during adulthood. Identifying the complex physiological and molecular pathways involved in modulation of pregnancy outcomes is thus of paramount importance for understanding and developing strategies to reduce adverse birth outcomes like preterm birth (PTB). Genetic markers alone may not provide sufficient in

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    sights into these processes. Epidemiologic observations, mostly from neonatal genomes, suggest probable role of epigenetic disruptions in enhancement of risk of PTB. However, very limited information is available on the role of maternal epigenome in PTB till date. My goal is to study the temporal variations in maternal DNA methylation landscape that occur during pregnancy and identify those that are associated with adverse outcomes.

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  • Kavya Vipparthi

    Kavya VipparthiSupervisor: SANDEEP SINGH

    Brief Description of Project

    My research goal is to explore the role of tumor initiating or cancer stem cells in oral squamous cell carcinoma, one of the most aggressive cancers in Indians with high rates of metastasis. According to Cancer Stem Cell theory, targeting stem-like cells would be more helpful rather than the whole tumor because only these cells would have the potential to self-renew and maintain tumor growth

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    and spreading while other cells do not. I am interested in learning the molecular mechanisms underlying the self- renewal and differentiation of stem-like cancer cells in oral cancer and how they contribute in tumor spread and metastasis. I am developing methods to identify and isolate these cells from oral-tumor tissue for its genomic and functional characterization. 

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  • Krittika Bhattacharyya

    Krittika BhattacharyyaSupervisor: SAMSIDDHI BHATTACHARJEE

    Brief Description of Project

    Identification of causal variants together with the potential mechanism contributing to differential disease risk among individuals can offer most critical insights into the proper understanding of complex diseases. So far, Genome-Wide Association Studies have been remarkably successful in identifying genetic variants associated with various complex diseases. However, the interpretation of G

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    WAS variants in terms of causality and the perception regarding the role played by these variants in the etiology of complex diseases have remained significantly ambiguous. Hence, we require robust statistical methods to efficiently integrate epigenomic and transcriptomic signatures and the intricate network of gene-regulation in relevant tissues along with functional annotations, pathways, and other evidence from publicly available databases. My primary interest lies in developing statistical methods for integrative analysis of multi-omics data to systematically identify causal variants within an associated region and to elucidate the causal mechanism through which they act. Methods developed will facilitate interpretation of complex disease associated loci not only to infer genetic causality through the epigenomic, transcriptomic and functional landscape in relevant tissues but also to highlight the upstream genes, pathways directly modulated by these genetic variants and consequent downstream changes.

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  • Manisha Rout

    Manisha RoutSupervisor: Saroj Kant Mohapatra

    Brief Description of Project

    Sepsis is a dysregulated host response to an infection. Often caused by antibiotic-resistant bacteria, it results in hospitalization and poor outcome, and accounts for nearly 20% of all global deaths annually.  The outcome of an infection depends on pathogen-factors such as virulence and antimicrobial resistance as well as host-factors such as the immune and inflammatory responses. My aim i

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    s to undertake a comprehensive study of K. pneumoniae-mediated sepsis by dissecting the pathogen-associated molecular characteristics that impinge upon host immuno-inflammatory response and evaluating its susceptibility to antimicrobial therapy. I am also looking to examine genes in clinical isolates of K. pneumoniae involved in perpetuating virulence and resistance and investigate the transcriptome of human neutrophil exposed to certain factors associated with pathogenesis.  Optimization of a suitable antimicrobial-combination therapy against K. pneumoniae is another important goal of my work.

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  • Moumita Mukherjee

    Moumita MukherjeeSupervisor: SRIKANTA GOSWAMI

    Brief Description of Project

    Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide with a lowest 5-year survival rate ( < 5% ) and poor diagnosis among other cancers. This intractable malignancy is often caused by some genetic alterations and also by pancreatic damage due to recurrent bouts of inflammation of chronic pancreatitis. In recent years, several regulatory functions of long non-coding

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    RNAs (lncRNAs) have come to picture which were initially considered to be junk elements of the genome with no function. Role of lncRNAs in various types of cancer has been gradually revealed and in the case of pancreatic cancer also, intricate role of lncRNAs have been uncovered with implications in cell cycle, apoptosis, autophagy, epithelial-mesenchymal transition (EMT), metastasis and immune responses. But still there are several important lncRNAs which have significantly altered expression in pancreatic cancer and their functions are yet to unfold. Aim of my research project is to functionally characterize few such lncRNAs in pancreatic carcinogenesis and also to find out if they have any role in progression of pancreatitis to pancreatic cancer. Read less
  • Mousumi Sarkar

    Mousumi SarkarSupervisor: SOUVIK MUKHERJEE

    Brief Description of Project

    Pregnancy is a complex physiological process associated with successive changes in the uterine environment that facilitates childbirth. The period of gestation varies from 37-42 weeks in Term Birth and < 37 weeks in Preterm Birth (PTB). Globally, PTB is one of the leading cause of child mortality and morbidity. Many preterm survivors face a lifetime of disability, including respiratory, learni

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    ng, visual disability and the number of premature babies is increasing exponentially with time. Identification of the complex aetiologies behind premature delivery is a big challenge worldwide. The vagina plays an important role in childbirth and is also home to a population of facultative and obligate anaerobic microorganisms that maintains the hygiene and pH of the vaginal milieu. This polymicrobial community is difficult to characterise through conventional microbiological culture based methods and are collectively termed as the Vaginal Microbiome. Recently, the role of oral as well as placental microbiome in preterm birth has also gained much interest. I am interested to investigate the change in composition and diversity of the Maternal Microbiome associated with Preterm birth in India. A multi-omics approach will be undertaken to dissect the host-microbiome interactions between host factors and differentially enriched microbial gene families as well as functional pathways that ultimately lead to Preterm Birth. Read less
  • Mr. Sudipta Chakraborty

    Mr. Sudipta ChakrabortySupervisor: Moulinath Acharya

    Brief Description of Project

    Primary angle closure glaucoma (PACG) is one of the leading causes of blindness worldwide with a complex genetic etiology. Several anatomical factors like shallow anterior chamber depth, increased lens thickness, narrow iridocorneal angle etc are involved in the pathogenesis of PACG which could raise intraocular pressure followed by optic neuropathy and subsequent blindness. In India, ~30%

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    peoples show narrow angle but 0.5-1% people actually develop PACG. To exclude heterogeneity, we conducted genome-wide association study (GWAS) between older (age ≥60 years) anatomically suspects (PACS) showing narrow angle <15> Read less
  • Paromita Mitra

    Paromita MitraSupervisor: SANDEEP SINGH

    Brief Description of Project

    Oral cancer is the most common cancer among Indian men. In spite of many therapeutic advancements, there has been no significant improvement in the survival outcome of head and neck squamous cell carcinoma. Five year survival rate in advanced stage  carcinoma is only 27% & it has high chance of relapse. Recently it is known that tumor microenvironment and stromal components (e.g- fibroblast

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    s, immune cells, endothelial cells), are as important as genetic mutations and play critical role in cancer development. Tumor contains different subpopulations in terms of mutations and make tumor heterogeneous. These subpopulations may differ in genetic, epigenetic level resulting in variation of the gene expression and protein function. However the reciprocal interaction between cancer cell and stromal component have not been studied in oral cancer. Therefore  I am interested in finding the interaction between heterogeneous tumor and its microenvironment. By understanding the cross-talk and reciprocal interaction between tumor cells and stromal components, we can predict novel target against tumor-stromal interaction.

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