Faculty Members

Research

Our laboratory primary research is focused on studying cellular metabolism implicated in chronic inflammatory diseases (colon, pancreatic and oral cancer) and resolution of inflammation. In the recent past, cellular metabolism has emerged as an integral process implicated in generating key signaling molecules associated with various cellular responses and processes including immune response, cell growth, apoptosis, and redox homeostasis. Often, cancer cells adopt dramatic metabolic phenotype to support proliferation and subsequent progression. Our lab is interested in understanding the factors that influence/regulate proteome and metabolome remodelling that facilitates such metabolic phenotype adaptations and develop potential therapeutic avenues.     

Our research interest also includes type-I diabetic specific identification of novel proteogenomic signatures associated with development of complications. Secondly, to develop sensitive, accurate, and reproducible measurement methods of biomolecules (especially proteins) to understand the pathophysiology and for biomarker discovery.

CV

Education

Professional Appointments

• Postdoctoral Scholar. Centre for Translational Biomedical Research, University of North Carolina, Greensboro. USA [2019 to 2021].
• Postdoctoral Scholar. Department of Veterinary and Biomedical Sciences, The Pennsylvania State University. USA [2016 to 2019].
• Research Fellow. Department of Biological Sciences, Nanyang Technological University. Singapore [2015 to 2016]
• CSIR Research Associate. Biochemical Sciences Division, CSIR-National Chemical Laboratory. India [2013 to 2015]

Professional Membership

• Life member of the Indian Society for Mass Spectrometry (LM693) [From 2008]
• Life member of Proteomics Society of India (Reg. No. 553) [From 2022] 
• Past member, American Society for Mass Spectrometry [From 2017 to 2021]
• Past member, American Society for Nutrition [From 2017 to 2019]

Honors and Awards

• NCL RF Gupta-Pardeshi-Sainani award for research scholars for best published research paper in biological sciences. Issuer: CSIR-National Chemical Laboratory Research Foundation. Pune, India-411008.
• Award of ‘Research Associate’ fellowship by CSIR, Government of India. April 2013
• Best poster and oral presentation at ‘International symposium- Proteomics beyond Ids’. CSIR- National Chemical Laboratory, Pune, India. November 2012.

Presentations

• The role of selenium in redox-dependent reversal of Warburg effect in macrophage polarization. KORWAR AM, Shay AE, Basrur V, Conlon K, Koo I, Smith PB, Patterson AD, Carlson BA, Prabhu KS. Nutrition 2018, the American Society for Nutrition's inaugural flagship meeting. June 9-12, 2018. Boston, MA (Poster presentation)
• Molecular profiling of breast cancer and identification of advanced glycation end products. KORWAR AM, Bhonsle HS, Kulkarni MJ International symposium- Proteomics beyond Ids’… Fourth Annual Meeting of Proteomics Society (India). November 22-24, 2012. CSIR-National Chemical Laboratory, Pune, India. (Poster presentation)

Publications

• Selenium-dependent metabolic reprogramming during inflammation and resolution. KORWAR AM, Hossain A, Lee TJ, Shay AE, Basrur V, Conlon K, Smith PB, Carlson BA, Salis HM, Patterson AD, Prabhu KS. (2021) J. Biol. Chem. Feb 10;296:100410. PMID: 33581115.
• Comprehensive Quantification of Carboxymethyllysine-Modified Peptides in Human Plasma. KORWAR AM, Zhang Q. (2021) J. Am. Soc. Mass Spectrom. Mar 3;32(3):744-752. PMID: 33512994.
• Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-derived Macrophages by nano-LC Orbitrap Fusion Tribrid Mass Spectrometry. KORWAR AM, Shay AE, Basrur V, Conlon K, Prabhu KS. (2019) J. Am. Soc. Mass Spectrom. Jul;30(7):1276-1283.
• The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. Diwakar BT, KORWAR AM, Paulson RF, Prabhu KS. (2017) Adv. Cancer Res. 2017;136:153- 172.
• Targeted Quantification of the Glycated Peptides of Human Serum Albumin. Vannuruswamy G, KORWAR AM, Jagadeeshaprasad MG, Kulkarni MJ. (2017) Methods Mol. Biol. 2017;1619:403-416.
• Molecules with O-acetyl Group Protect Protein Glycation by Acetylating Lysine Residues. Vannuruswamy G, Jagadeeshaprasad MG, K. Kashinath, Suresh KK, Bhat SP, KORWAR AM, Chougale AD, Boppana R, Reddy DS, Kulkarni MJ. (2016) RSC Advances. 2016;6: 65572-65578.
• Targeted quantification of N-1-(carboxymethyl) valine and N-1-(carboxyethyl) valine peptides of β- hemoglobin for better diagnostics in diabetes. Jagadeeshaprasad MG, Batkulwar K, Meshram N, Tiwari S, KORWAR AM, Unnikrishnan AG, Kulkarni MJ. (2016) Clinical Proteomics. 2016 Mar 29;13:7.
• Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights. Singh P, Jayaramaiah RH, Agawane SB, Vannuruswamy G, KORWAR AM, Anand A, Dhaygude VS, Shaikh ML, Joshi RS, Boppana R, Kulkarni MJ, Thulasiram HV, Giri AP. (2016) Scientific Reports. 2016 Jan 7;6:18798.
• Development of diagnostic fragment ion library for AGE modified peptides of Human serum albumin: Their use in targeted quantification using PRM, SWATH and MS. KORWAR AM, Vannuruswamy G, Jagadeeshaprasad MG, Jayaramaiah RH, Bhat S, Regin BS, Ramaswamy S, Giri AP, Mohan V, Balasubramanyam M, Kulkarni MJ. (2015) Mol. Cell. Proteomics 2015 Aug; 14(8):2150-9.
• Recent development of plant products with anti-glycation activity: a review Chinchansure AA, KORWAR AM, Kulkarni MJ and Joshi SP. (2015) RSC Advances. 2015,5, 31113-31138. DOI: 10.1039/C4RA14211J.
• Proteomic profiling and interactome analysis of ER-positive/HER2/neu negative invasive ductal carcinoma of the breast: towards proteomics biomarkers. KORWAR AM, Bhonsle HS, Ghole VS, Gawai KR, Koppikar CB, Kulkarni MJ. (2013) OMICS: A journal of Integrative Biology. 2013; 17(1):27-40.
• Proteomic study reveals downregulation of apolipoprotein A1 in plasma of poorly controlled diabetes: a pilot study. Bhonsle HS, KORWAR AM, Chougale AD, Kote SS, Dhande NL, Shelgikar KM, Kulkarni MJ. (2013) Molecular Medicine Reports. 2013; 7(2):495-8.
• Glycated proteome: from reaction to intervention. Kulkarni MJ, KORWAR AM, Mary S, Bhonsle HS, Giri AP. (2013) Proteomics Clin. Appl. 2013; 7(1-2):155-70.
• Analysis of AGE modified proteins and RAGE expression in HER2/ neu negative invasive ductal carcinoma. Korwar AM, Bhonsle HS, Chougale AD, Kote SS, Gawai KR, Ghole VS, Koppikar CB, Kulkarni MJ. (2012) Biochem Biophys Res Commun. 2012; 419(3):490- 4.
• "Zoom-ln"--A targeted database search for identification of glycation modifications analyzed by untargeted tandem mass spectrometry. Bhonsle HS, Korwar AM, Kesavan SK, Bhosale SD, Bansode SB, Kulkarni MJ. (2012) Eur. J. Mass Spectrom. (Chichester, Eng). 2012; 18(6):475-81.
• Low plasma albumin levels are associated with increased plasma protein glycation and HbA1c in diabetes.Bhonsle HS, Korwar AM, Kote SS, Golegaonkar SB, Chougale AD, Shaik ML, Dhande NL, Giri AP, Shelgikar KM, Boppana R, Kulkarni MJ. (2012) J. Proteome Res. 2012; 11(2):1391- 6.

Lab members

PhD Student