Breast cancer is one of the most common cancers and the second most leading of cancer death in women. Breast cancer is hormone dependent tumor and estrogen is known to play a major role in the initiation and progression of this cancer. Endocrine therapy is the best therapy for breast cancer. But resistance to endocrine therapy is common. Previous studies account for only 40% of such mechanis
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Tuberculosis is a potentially serious infectious disease and still a major health problem worldwide. Pathogenesis of this disease is driven by a complex interaction between the host immune system and immune escaping strategies of the pathogen. Cytokines and chemokines produced by host immune cells play vital role in elimination of infection. Bio fluid level of one such chemokine, CXCL10,
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Among the recently discovered Type–III interferon family, IFN-λ4 (IFNL4) is thenewest member. I am interested in characterizing the naturally occurring variants of IFNL4 gene for their effect on IFN-λ4’s function and their significance in different human diseases. IFNL4 gene transcription is known to generate several different splice variants. I am also interested to understand if any
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Congenital muscular dystrophies (CMD) and congenital myopathies (CM) are a group of rare genetically and clinically heterogeneous degenerative primary muscle disorders with onset at birth or during infancy. Due to vast heterogeneity, clinical examination and protein-based analyses often fail to identify the genetic causes of these diseases making it challenging for the clinician to make an a
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Oral squamous cell carcinoma of the gingivo-buccal region (OSCC-GB) is a form of Head and Neck Squamous cell carcinoma (HNSCC). Recent epidemiological studies reported – (i) India has one-third of all oral cancer cases in the world and (ii) oral cancer accounts for 30% of all cancers reported from India. Oral cancer is the topmost cancer among males in India and link
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Genome wide association studies (GWAS) are used to discover association of genetic variants with various complex diseases and traits. However, testing markers across the genome in an unbiased manner leads to loss of power for such studies. My research project deals with increasing the power of such genome wide studies by incorporating information from other sources. Knowledge from pathways,
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Human oral squamous cell carcinoma (OSCC) is the eighth most common cancer worldwide; and, the most prevalent cancer among men and fourth most common among women in India. Owing to the highly heterogeneous nature of oral carcinoma at both cellular and molecular levels, it is important to investigate the functions of altered pathways with respect to distinct cancer cell-types present wit
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Intratumor heterogeneity is among the greatest challenges in treatment of cancer. In spite of disruptive advances in sequencing technologies achieved over the last decade, high resolution comprehension of such heterogeneity has been beyond our reach until recently. Developments in high-throughput Single Cell RNA-Seq (SC-RNASEQ) may now enable us to dissect the diverse cellular populations of
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An individual is provided medication, whether vaccine or drug, without taking into account the genomic background of the individual; i.e., a one-size-fits-all approach is used. However, it is known that genetic differences strongly account for inter-individual variability in treatment response, leading to huge wastage of funds and resources. This economic burden can be drastically minimize
Read MoreAim of the current study is to identify the genomic correlates of medication response to design a well represented panel of pharmacogenetic markers which will enable screening of individuals. These will help clinicians in selection of appropriate drug and genotype-specific dose. With plummeting cost of DNA sequencing technologies, genetic testing using such a panel will augment clinical decision making to meet personalized needs of each patient providing quality health care, while preventing adverse events and improve many lives.
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