Human Disease Models (Genetic & Infectious Models), Simulation Studies (Modeling & Immunoinformatics), Stem Cell / CAR-T Cell Translational Therapies.
Overall research focus of our laboratory is to understand and gain insights for; Why some individuals respond with severe, threatening diseases, whereas others display a quiescent progression, or even remain asymptomatic following stimulus challenge.
In particular, the lab is keenly interested in unraveling cellular/molecular or genetic mechanisms underlying in the healthy and disease aiming for translational approaches.
Two major focus areas that the lab is working on LUNG BIOLOGY & RETINAL BIOLOGY:
Emphasis is placed on infectious diseases of the lung, associated tropical infections, thus fostering in understanding the underlying pathologies of chronic lung diseases. Special emphasis is placed on delineating genetic variants or molecular signaling pathways at multiple levels from single cells, to tissues, entire organs in COPD disorder.
We hypothesize the key gene regulators or variants (like NLRP3 variants) in different individuals, suggests the inter-individual differences that determine severe, life-threatening conditions following microbial challenge. We aim to screen and evaluate the unstudied or update our existing knowledge regarding the mechanisms by which pathogens influence inflammose activation (NLRP3) and regulate immune cells profiles.
Our study findings will demonstrate unexplored heterogenic prototype study of Indian population to decipher the mechanistic events of NLRP3 mediated pulmonary disease progression. It will also establish methods for the utility of HLMSCs or CART-cell as cell therapeutic intervention to circumvent pulmonary (COPD) disorders.
Inherited retinal degenerations (IRDs) are the group of genetically heterogeneous conditions with a broad phenotypic heterogeneity. Research focus on understanding the molecular genetics of macular and retinal dystrophy, biological mechanisms underlying retinal diseases, age-related macular degeneration and viral associated (HSV). The laboratory study research strategy involves identifying mutations in novel genes causing IRDs, understanding the function of these genes, determining the pathways that are involved in causing disease pathology and evaluating novel therapeutic interventions to delay the onset or treat the progression of degeneration. Our research findings have identified the genetic determinants (IFT43, IFT88, MERTK) responsible for retinal degeneration in different descent of families. Our studies have investigated the clinical characteristics and genetic basis of inherited retinal degeneration (IRD) and functional aspects in different pedigrees. Our studies evaluated the whole genome and exome sequencing of several patients and generated stem cell and mouse models that enabled discovery of novel disease causing genes. Our long term studies aim to describe the genomic architecture of patient DNA, transcriptome and proteome profiles of patient derived stem cell and animal models. Studies will facilitate to identify non-coding and coding variants, modifiers associated with disease progression and predictive modeling.
Our distinctive study approaches will lead to address the disease phenotype, functions or progression and disease regulation applications. Multidisciplinary approaches and cutting edge technologies will be employed on Animal models or Human tissue samples / Patient data, and Simulation Studies (Modeling & Immunoinformatics) will offer unique opportunities to define new therapeutic targets.
|2010||Ph.D.||Sri Krishnadevaraya University / (CDFD, Hyderabad)|
|2004||M.Sc.||Sri Krishnadevaraya University|
|2001||B.Sc.||Sri Krishnadevaraya University|