Complex diseases are caused by interaction of multiple genes and environmental factors. We know that complex diseases do not follow the standard Mendelian patterns of inheritance. Although we inherit genes associated with these diseases, genetic factors are responsible only for partial risk associated with complex disease phenotypes. Epigenetic factors are also known to play important role along with environmental and life-style factors and it is very important to understand their relative contribution in modulating the overall pathophysiology of the disease.
Broadly, the interest of our laboratory is to identify genes, loci and epigenetic changes that confer susceptibility to some complex disorders, to elucidate how they influence the pathogenesis, and to translate this information into improved patient care both in terms of better diagnosis of the disease and better treatment options.
Currently, we are focusing on several gastrointestinal diseases.
Chronic Pancreatitis (CP) is a disease of the pancreas where progressive inflammation of the organ ultimately leads to the destruction of both exocrine and endocrine part of pancreas resulting in high morbidity and mortality. The disease also increases the susceptibility of the patients to develop pancreatic ductal adenocarcinoma (PDAC) representing a classic model of progression of chronic inflammation to malignancy. Notably, PDAC is one of the most aggressive cancers lacking early diagnostic biomarkers. We aim to:
The following figure, adopted from Chhatriya et al., PINSA., Vol 84 No 2 (2018):501-511; summarizes the core area of our research interest
Another area of interest is early onset aggressive subtype of colorectal cancer in Indian population as described by Raman R et al. (Mol Carcinog. 2014 Feb; 53(0 1): E181–E186). We plan to investigate the genetic and epigenetic underpinnings of the disease and aim to relate them to the actual mechanism. Role of microsatellite instability will also be explored.
Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Barsha Saha, Somdatta Lahiri, Sandip Halder, Indranil Ghosh, Sujan Khamrui, Kshaunish Das, Samsiddhi Bhattacharjee, Saroj Kant Mohapatra, Srikanta Goswami; Transcriptome analysis identifies putative multi-gene signature distinguishing benign and malignant pancreatic head mass; J Transl Med. 2020 Nov 7;18(1):420. doi: 10.1186/s12967-020-02597-1; PMID: 33160365
Moumita Mukherjee, Srikanta Goswami; Global cataloguing of variations in untranslated regions of viral genome and prediction of key host RNA binding protein-microRNA interactions modulating genome stability in SARS-CoV2; bioRxiv 2020.06.09.134585; doi: https://doi.org/10.1101/2020.06.09.134585 / PLOS ONE; August 11, 2020; https://doi.org/10.1371/journal.pone.0237559; PMID: 32780783
Bishnupriya Chhatriya, Piyali Sarkar, Debashis Nath, Sukanta Ray, Kshaunish Das, Saroj Kant Mohapatra and Srikanta Goswami. Pilot study identifying circulating miRNA signature specific to alcoholic chronic pancreatitis and its implication on alcohol mediated pancreatic tissue injury; JGH OPEN., (July 15, 2020; https://doi.org/10.1002/jgh3.12389)
Chhatriya B, Paine SK, Das S, Chatterjee A, Nath D, Mukherjee A, Basu A, Goswami S. Single nucleotide polymorphisms in PRSS1 and CASR genes are associated with chronic pancreatitis in North-Eastern region of India; J Gastrointestin Liver Dis. 2020 Jun 4;29(2):267-268. doi: 10.15403/jgld-788.; PMID: 32530995
Chhatriya B, Mukherjee M, Ray S, Sarkar P, Chatterjee S, Nath D, Das K, Goswami S; Comparison of tumour and serum specific microRNA changes dissecting their role in pancreatic ductal adenocarcinoma: a meta-analysis; BMC Cancer. 2019 Dec 3;19(1):1175. doi: 10.1186/s12885-019-6380-z; PMID: 31795960