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RESEARCH | CURRICULUM VITAE | PUBLICATIONS      

 Name: MOULINATH ACHARYA

  Email:   ma1

 Present Position:  Assistant Professor

 Highest educational Qualification:  Ph.D.

Publications:

 

Disease-Phenotype Deconvolution in Genetic Eye Diseases Using Online Mendelian Inheritance in Man. Pandey P, ACHARYA M (2016) Investigative Ophthalmology & Visual ScienceMay 1; 57(6):2567-76.


Amyloid Beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development. Kaiser DM#, ACHARYA M#, Leighton PL#, Wang H, Daude N, Wohlgemuth S, Shi B, Allison WT (2012) PLOS ONE. 7(12):e51305. doi: 10.1371/journal.pone.0051305 # equal contribution


Yeast two-hybrid analysis of a human trabecular meshwork cDNA library identified EFEMP2 as a novel PITX2 interacting protein. ACHARYA M, Sharp MW, Mirzayans F, Footz T, Huang L, Birdi C, Walter MA (2012) Molecular Vision 18:2182-2189


Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis. Mookherjee S, ACHARYA M, Banerjee D, Bhattacharjee A, Ray K (2012) PLOS ONE. 7(9): e45077 doi:10.1371/journal.pone.0045077


A complex regulatory network of transcription factors critical for ocular development and disease. ACHARYA M*, Huang L, Fleisch VF, Allison WT, Walter MA (2011) Human Molecular Genetics Apr 15; 20(8):1610-24 *corresponding author


Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells. ACHARYA M, Lingenfelter DJ, Huang L, Gage PJ, Walter MA (2009) Journal of Biological Chemistry Dec 11; 284(50): 34829-38


Analysis of mutations of the PITX2 transcription factor found in Axenfeld-Rieger Syndrome patients.Footz T, Idrees F, ACHARYA M, Kozlowski K, Walter MA (2009) Investigative Ophthalmology & Visual Science Jun; 50(6): 2599-606.


Complex genetics of glaucoma: Defects in CYP1B1, and not MYOC, cause pathogenesis in an early-onset POAG patient with double variants at both loci. ACHARYA M#, Mukhopadhyay A#, Bhattacharjee A, Thakur SKD, Bandyopadhyay AK, Ray K (2008) Journal of Genetics 87:3. 265-9. #equal contribution


Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma. Bhattacharjee A, Banerjee D, Mookherjee S, ACHARYA M, Banerjee A, Ray A, Sen A, IGVS, Ray K (2008) Molecular Vision 14, 841-50


Evaluation of the Opticin gene in primary open angle glaucoma: functional significance of a silent change. ACHARYA M, Mookherjee S, Bhattacharjee A, Thakur SKD, Bandyopadhyay AK, Sen A, Chakrabarti S, Ray K (2007) BMC Molecular Biology, 8:21


Myocilin variants in Indian open angle glaucoma patients. Bhattacharjee A, ACHARYA M, Mukhopadhyay A, Mookherjee S, Banerjee D,  Bandyopadhyay AK, Thakur SKD, Sen A, Ray K (2007) Archives of Ophthalmology 125(6): 823-9


Primary role of CYP1B1 in Indian juvenile-onset POAG patients. ACHARYA M, Mookherjee S, Bhattacharjee A, Bandyopadhyay AK, Thakur SKD, Bhaduri G, Sen A, Ray K (2006) Molecular Vision 12, 399-404


Evaluation of Optineurin as a candidate gene in Indian patients with primary open angle glaucoma. Mukhopadhyay A#, Komatireddy S#, ACHARYA M, Bhattacharjee A, Mandal AK, Thakur SKD, Chandrasekhar G, Bandyopadhyay AK, Thomas R, Chakrabarti S, Ray K (2005), Molecular Vision 11, 792-97 #equal contribution


Gln48His is the prevalent myocilin mutation in primary open angle and primary congenital glaucoma phenotypes in India. Chakrabarti S, Kaur K, Komatireddy S, ACHARYA M, Devi KR, Mukhopadhyay A, Mandal AK, Hasnain SE, Chandrasekhar G, Thomas R, Ray K (2005), Molecular Vision 11, 111-13


Myocilin mutation 1109 C>T (Pro 370 Leu) is the most common gene defect causing early onset primary open angle glaucoma. Mukhopadhyay A, ACHARYA M, Ray J, Khan M, Sarkar K, Banerjee AR, Ray K (2003), Indian Journal of Ophthalmology 51 (3), 279-81


Mutations in MYOC gene of Indian primary open angle glaucoma patients. Mukhopadhyay A, ACHARYA M, Mukherjee S, Ray J, Choudhury S, Khan M, Ray K (2002), Molecular Vision 8, 442-48


Distribution of p53 codon 72 polymorphism in Indian primary open angle glaucoma patients. ACHARYA M#, Mitra S#, Mukhopadhyay A, Khan M, Roychoudhury S, Ray K (2002), Molecular Vision 8, 367-71. #equal contribution

 

Review article publications

Role of myocilin in glaucoma: Molecular defects and possible functional aberrations leading to pathogenesis Bhattacharjee A, ACHARYA M, Mookherjee S, Banerjee S, Mukhopadhyay A, Bandyopadhyay AK, Thakur SKD, Sen A, Ray K (2006) Asian Journal of Experimental Science 20, 97-112


Genetics and bioinformatics of primary open angle glaucoma: an Indian perspective. Ray K, Thakur SKD, Bandyopadhyay AK, Mukhopadhyay A, ACHARYA M, Bhattacharjee A, Sen A, Bhaduri G (2004), Journal of Indian Medical Association 102 (12): 708-12


Recent Advances in Molecular Genetics of Glaucoma. Ray K, Mukhopadhyay A, ACHARYA M (2003), Molecular & Cellular Biochemistry 253: 223-31

 

Book Chapter

Molecular Genetics of Congenital and Juvenile Glaucoma. ENCYCLOPEDIA OF THE EYE ACHARYA M and Walter MA (2010), Elsevier

 

Contribution in Indian Genome Variation Consortium core publications

Genetic landscape of the people of India: a canvas for disease gene exploration. Indian Genome Variation Consortium (2008) Journal of Genetics 87:1. 3-20 Apr


The Indian Genome Variation database (IGVdb): a project overview. Indian Genome Variation Consortium (2005) Human Genetics 118: 1. 1-11 Oct

 

 

Published Annotation of genetic variations

Gene symbol: CYP1B1 p.Ser515Leu Ray K, ACHARYA M, Mookherjee S (2007). Human Genetics 121(2):292

Gene symbol: CYP1B1 p.Asp530Gly Ray K, ACHARYA M, Mookherjee S (2007). Human Genetics 121(2):291

Gene symbol: CYP1B1 p.Arg523Thr Ray K, ACHARYA M, Mookherjee S (2007). Human Genetics 121(2):291

Gene symbol: CYP1B1 p.Glu230Lys Ray K, ACHARYA M (2007). Human Genetics 121(2):291

Gene symbol: MYOC p.Gly399Asp Ray K, Mukhopadhyay A, ACHARYA M (2007). Human Genetics 121(2):290-1


 

 

Patent(s): none