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Name:  SANDEEP SINGH

Email:   ss5

Present Position:  Assistant Professor

                              Intermediate Fellow of Wellcome Trust/DBT India Alliance

Highest educational Qualification:  Ph.D.

   

Research:

In opposite to the prevailing theory where all the cancer cells have equal and similar proliferative capacity and opportunity for regenerating tumor growth and spread, a school of thought suggests that cancers are organized into aberrant cell hierarchies where it is mainly driven by a subset of cancer cells called ‘stem-like cancer cells’ that have the ability to self-renew themselves and generate the heterogeneous lineages of other cells types that comprise the whole tumor. It is believed that oncogenic transformations of the normal stem cells or the progenitor cells results in deregulated self-renewal and give rise to stem-like cancer cells. Aberrant symmetric or asymmetric cell division maintains the number of stem-like cancer cells within the tumor, whereas its descendent progeny constitute the bulk of the heterogeneous tumor. The descendant cancer cells eventually become terminally differentiated and stop dividing, therefore are non-tumorigenic. Stem-like cancer cells may remain dormant, evade offered therapy or metastasize to recapitulate the tumor growth. Being the only cell type with extensive replicative potential and cancer driving ability, my research goal is to comprehend the biology of the stem-like cancer cells with respect to their self-renewal, differentiation, functional heterogeneity and interactions with its niche within solid tumors.

Our Laboratory is currently interested in-

(a) Establishing the platform for isolation, purification and characterization of SLCCs from oral tumors

(b) Understanding heterogeneity among Oral-SLCCs and its functional consequences

(c) Exploring the role of tumor-microenvironment  in oral cancer progression 

 

Selected Publications:

Singh S, Chellappan S. Lung cancer stem cells: Molecular features and therapeutic targets. Mol Aspects Med. 2013 Sep 7. pii: S0098-2997(13)00061-7. doi: 10.1016/j.mam.2013.08.003. PubMed PMID: 24016594

Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP. EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer. Mol Cancer. 2012 Sep 25;11:73. PubMed PMID: 23009336

Singh S, Chellappan SP. The biology of lung cancer stem cells. Stem Cells and Human Diseases. 2012, 509-532 (Book Chapter)