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 Name: PARAMITA BHATTACHARYA

  Email:  pb2[at]nibmg.ac.in

 Present Position:  Genetic Laboratory Scientist

 Highest educational Qualification: PhD

Research 

Research interests:

Understanding the role of genetic and epigenetic changes in modifying disease pathogenesis and response to treatment

Studying the transcriptional regulation of genes in disease context to identify therapeutic targets

Identifying novel genetic variations causing rare genetic diseases

Estimating the prevalence of monogenic disorders and the frequency of the pathogenic alleles associated with the disorder in Indian population

Selected publications:

  1. Rozenberg JM, Bhattacharya P, Chatterjee R, Glass K, Vinson C. Combinatorial recruitment of CREB, C/EBPb and c-Jun determines activation of promoters upon keratinocyte differentiation. PLoS ONE 8(11): e78179; 2013. doi:10.1371/journal.pone.0078179
  2. Rishi V*, Bhattacharya P*, Chatterjee R*, Rozenberg J*, Zhao J*, Glass K, Fitzgerald P, and Vinson C. CpG methylation of half-CRE sequences creates C/EBPα binding sites that activate some tissue-specific genes. Proceedings of the National Academy of Sciences of the United States of America, 107: 20311-20316; 2010. (*These authors are considered co-first authors.)
  3. Bhattacharya P and Sengupta S. Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03. Tissue Antigens, 70: 283-293; 2007. doi: 10.1111/j.1399-0039.2007.00894.x
  4. Bhattacharya P, Duttagupta C and Sengupta S. Proline homozygosity in codon 72 of p53: A Risk genotype for Human papillomavirus related cervical cancer in Indian women. Cancer Letters, 188: 207-211; 2002. doi.org/10.1016/S0304-3835(02)00430-5
  5.  Bairagya BB, Bhattacharya P, Bhattacharya SK, Dey B, Dey U, Ghosh T, Maiti S, Majumder PP, and et al. Genetic variation and haplotype structures of innate immunity genes in eastern India. Infection, Genetics and Evolution, 8: 360-366; 2008. (Authors are listed in alphabetical order.) doi:10.1016/j.meegid.2008.02.009
 

EDUCATION

1993-1996            BSc with Zoology (Hons.), Calcutta University, Kolkata

1996-1998            MSc in Zoology, Visva Bharati, Santiniketan

1999-2005            PhD (Science), Jadavpur University, Kolkata (work done at India Indian Statistical Institute, Kolkata)

POSITIONS HELD

July 2015 – June 2017

Position      Principal Investigator, DST-Women Scientist (WOS-A Scheme)

Institute     Division of Cancer Biology & Inflammatory Disorder, CSIR-Indian Institute of   Chemical Biology, Kolkata

February 2015 – June 2015

Position     Senior Research Associate (CSIR-Scientist’s Pool Scheme)

Institute    Division of Cancer Biology & Inflammatory Disorder, CSIR-Indian Institute of Chemical Biology, Kolkata

July 2011 – July 2013

Position        Postdoctoral Fellow

Institute       Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata

April 2007 – July 2010

Position        Postdoctoral Fellow (Exchange Visiting Program)

Institute       Gene Regulation Section, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, USA

October 2005 – March 2007

Position        Research Associate / Staff

Institute       TCG-ISI Centre for Population Genomics, Indian Institute of Molecular Medicine

September 1999- October 2005

Position        Research Fellow (JRF/SRF), Ph.D. programme, Indian Statistical Institute

Institute       Indian Statistical Institute, Kolkata

2005             

Position        Visiting Lecturer

Institute       Dept. of Biotechnology, Institute of Technology and Marine Engineering, India.

Invited oral presentations in scientific meetings

2005                  DBT-NCBS Cancer Brainstorming Workshop, NCBS, Bangalore, India (Invited Speaker)

2010                  10th NCI CCR Fellows and Young Investigators Colloquium, PA, USA  (Selected speaker)

Invited oral presentations in seminars

 2006                  Gene Regulation Section, NCI, NIH.

 2007                  Stanley Group Meeting, NIH, Bethesda, USA.

 2009                  Department of Microbiology, Bose Institute, Kolkata, India.

 2011                  Calcutta Consortium for Human Genetics, Dept. of Genetics, Ballygunge Science College, University of Calcutta

 2011                  Human Genetics Unit, Indian Statistical Institute, Kolkata, India.

 

PUBLICATIONS

  • Rozenberg JM, Bhattacharya P, Chatterjee R, Glass K, Vinson C. Combinatorial recruitment of CREB, C/EBPb and c-Jun determines activation of promoters upon keratinocyte differentiation. PLoS ONE 8(11): e78179; 2013.
  • Chatterjee R, Bhattacharya P, Gavrilova O, Glass K, Moitra J, Myakishev M, Pack S, Jou W, Feigenbaum L, Eckhaus M, and Vinson C. Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy. Journal of Molecular Endocrinology, 46: 175-192; 2011.
  • Sarkar N, Mondal D, Bhattacharya P, Majumder PP. A novel statistical algorithm for maximizing the utility of HapMap Data to design genetic association studies in non-HapMap populations. International Journal of Data Mining and Bioinformatic, 5 (6): 706-716; 2011.
  • Rishi V*, Bhattacharya P*, Chatterjee R*, Rozenberg J*, Zhao J*, Glass K, Fitzgerald P, and Vinson C. CpG methylation of half-CRE sequences creates C/EBP binding sites that activate some tissue-specific genes. Proceedings of the National Academy of Sciences of the United States of America, 107: 20311-20316; 2010. (*These authors are considered co-first authors.)
  • Bairagya BB, Bhattacharya P, Bhattacharya SK, Dey B, Dey U, Ghosh T, Maiti S, Majumder PP, and et al. Genetic variation and haplotype structures of innate immunity genes in eastern India. Infection, Genetics and Evolution, 8: 360-366; 2008. (Authors are listed in alphabetical order.) 
  • Bhattacharya P and Sengupta S. Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03. Tissue Antigens, 70: 283-293; 2007. 
  • Laikangbam P, Sengupta S, Bhattacharya P, Duttagupta C, Singh Th D, Verma Y, Roy S, Das R and Mukhopadhyay S. A comparative profile of the prevalence and age-distribution of human papillomavirus type 16/18 infections among three states of India with focus on Northeast India. Int J Gynecol Cancer, 17: 107-117; 2007. 
  • Bhattacharya P, Shankarkumar U and Sengupta S. HLA B*1301 and B*1801 alleles are Positively Associated with HPV Related Cervical Cancer in Women from Kolkata, Eastern India. Int J Hum Genet, 6(2): 139-144; 2006.
  • Bhattacharya P and Sengupta S. Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21 jointly mediate cervical cancer susceptibility among Indian women. Gyn Oncol, 99(1): 175-181; 2005.
  • Bhattacharya P and Sengupta S. HLA DQB1*03 genotypes and susceptibility to cervical cancer in Indian women. Int J Hum Genet, 5(1): 19-25; 2005.
  • Duttagupta C, Sengupta S, Roy M, Sengupta D, Bhattacharya P, Laikangbam P, Roy S and Ghosh S. Are Muslim women less susceptible to oncogenic human papillomavirus infection? : Study from rural eastern India. Int J Gynecol Cancer, 14(2): 293-303; 2004.
  • Bhattacharya P, Duttagupta C and Sengupta S. Proline homozygosity in codon 72 of p53: A Risk genotype for Human papillomavirus related cervical cancer in Indian women. Cancer Letters, 188: 207-211; 2002.
  • Duttagupta C, Sengupta S, Roy M, Sengupta D, Chakraborty S, Bhattacharya P, Roy S and Ghosh S. Oncogenic HPV infection and uterine cervical cancer: A screening strategy in the perspective of rural India. Eur J Cancer Prev, 11(5): 447-456; 2002.
  • Ray M, Sengupta S, Bhattacharya P and Duttagupta C. Human papillomavirus and uterine cervical cancer: State of the art. Science and Culture, 67: 205-211; 2001.