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Name:  NIDHAN K. BISWAS

Email:   

Present Position: Assistant Professor

Highest educational Qualification:  Ph.D.

Research:

With the huge advances in DNA sequencing technology and computational algorithms, it is now possible to identify genomic alterations of a cancer genome in an unprecedented way. The present day massively parallel DNA sequencers can generate several terabytes of sequence data in a day. We develop automated pipelines to analyze these large multi-omics datasets to answer important scientific questions in cancer and population genomics. In particular, my current research is focused on applying these computational methods to understand and study (i) genomic landscape of oral pre-cancer, (ii) tumour heterogeneity in oral cancer and (ii) how tumour heterogeneity modulates local lymph-node metastasis.

I am also engaged as the group leader of bioinformatics and statistical wing of the International Cancer Genome Consortium (ICGC) – India project and SyMeC project on oral cancer. In these projects, we are identifying the nature and extent of genomic alterations in Indian oral cancer patients. We are generating and analyzing whole-exome, whole-genome DNA sequencing and RNA-sequencing data on multiple gingivo-buccal oral cancer patients to discover the complete repertoire of genomic alteration of the patients and possible therapeutic options.

In past, I have worked extensively in human evolutionary genetics with special reference to natural selection. I have continued interest in human evolution and human population genetics. Presently, I am working with my colleagues in projects on whole genome sequencing data from multiple Indian ethnic population samples to understand baseline genome variation in healthy individuals.

 

Selected Publications:

  • * Biswas NK, Das C, Das S, Maitra A, Nair S, Gupta T, D'Cruz AK, Sarin R, Majumder PP. Lymph node metastasis in oral cancer is strongly associated with chromosomal instability and DNA repair defects. Int J Cancer. 2019 Mar 28. doi: 10.1002/ijc.32305. [Epub ahead of print] PubMed PMID: 30924133

  • Palodhi A, Ghosh S, Biswas NK, Basu A, Majumder PP, Maitra A (2018). Profiling of genomic alterations of mitochondrial DNA in gingivobuccal oral squamous cell carcinoma: Implications for disease progress. Mitochondrion. 46:361-369. doi: 10.1016/j.mito.2018.09.006.

  • Biswas NK, Chandra V, Sarkar-Roy N, Das T, Bhattacharya RN, Tripathy LN, Basu SK, Kumar S, Das S, Chatterjee A, Mukherjee A,Basu P, Maitra A, Chattopadhyay A, Basu A, Dhara S. (2015) Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM. Sci Rep. 5:7915.

  • Biswas NK*, Das S, Maitra A, Sarin R, Majumder PP. (2014) Somatic mutations in arachidonic acid metabolism pathway genes enhance oral cancer post-treatment disease-free survival. Nat Commun. ;5:5835. doi: 10.1038/ncomms6835.

  • India Project Team of the International Cancer Genome Consortium. (2013). Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nature Communications. ;4:2873. doi: 10.1038/ncomms3873.  [ Maitra A, Biswas NK, Amin K, Kowtal P, Kumar S, Das S, Sarin R, Majumder PP, Bagchi I, Bairagya BB, Basu A, Bhan MK, Chaturvedi P, Das D, D'Cruz A, Dhar R, Dutta D, Ganguli D, Gera P, Gupta T, Mahapatra S, Mujawar MH, Mukherjee S, Nair S, Nikam S, Nobre M, Patil A, Patra S, Rama-Gowtham M, Rao TS, Roy B, Roychowdhury B, Sarkar D, Sarkar S, Sarkar-Roy N, Sutradhar D. ]

​*Corresponding Author