Research Interests Population Genetics, Genetic Epidemiology, Statistical Genetics
My research interest is nested. There are two major components; one is to understand human genome diversity and evolution with special reference to India. This endeavor of understanding human genetic diversity and structure, not only provides us a window into human pre-history or understanding socio-cultural norms in historic times influencing social behavior; it also provides the framework to look at the multifactorial nature of disease causation considering host and exposure factors together. This automatically introduces the second component of my research, which is aimed at identification of genomic regions responsible for differential expression of heritable traits, i.e. connecting genotype with the phenotype. However, it is nested because I often work on problems where there are no off-the-shelf statistical methods. Thus, an important part of my work is in developing appropriate statistical and computational approaches that can yield new insights into biological data.
Awards & Honours
Fellow of the West Bengal Association of Science and Technology, December 2016
Young Investigator Award at the 12th International Congress of Human Genetics/ 61st American Society of Human Genetics Meeting, Montreal 2011
Integrating Multi-Omics Data Using Big Data Analytics to Infer Optimal Wellness Trajectories for Management of Non-communicable diseases (NCDs): Cervical Cancer as an Exemplar (Department of BioTechnology (DBT), Government of India)
Unbiased Profiling of Loci Relevant for Pharmacogenomics, Pharmacovigilance and Predisposition to Some Common Disorders in a Peri-Urban Population of West Bengal (Department of BioTechnology, Government of West Bengal)
A Unified Web-portal for Analysis, Integration and Visualization of Multi-omics Data (Department of BioTechnology (DBT), Government of India)
BASU A*, Sarkar-Roy N, Majumder PP (2016) Genomic reconstruction of the history of extant populations of India reveals five distinct ancestral components and a complex structure. Proceedings of the National Academy of Sciences U S A. Feb 9;113(6):1594-9.
Narang A, Jha P, Rawat V, Mukhopadhayay A, Dash D, BASU A*, Mukerji M (2011) Recent Admixture in an Indian Population of African Ancestry. American Journal of Human Genetics 89(1): 111 – 120.
BASU A*, Tang H, Lewis CE, North K, Curb DJ, Quertermous T, Mosley TH, Boerwinkle E, Zhu X, Risch N (2009) Admixture Mapping of Quantitative Trait Loci for Blood Lipids in African Americans. Human Molecular Genetics 18(11):2091-98.
BASU A, Chaudhuri P, Majumder PP. (2005) Identification of polymorphic motifs using probabilistic search algorithms. Genome Research 15(1):67-77
BASU A, Mukherjee N, Roy S, Sengupta S, Banerjee S, Chakraborty M, Dey B, Roy M, Roy B, Bhattacharyya NP, Roychoudhury S, Majumder PP (2003) Ethnic India: a genomic view, with special reference to peopling and structure. Genome Research 13(10):2277-90