BRIC-NIBMG | BRIC National Institute of Biomedical Genomics

BLM regulates MALT1-driven NF-κB signalling and is targetable in B-cell malignancies.

Agrawal, R., Ghosh, S., Kumar, N., Mukherjee, C., Sharma, V., Arun, R., Deb, R., Sarkar, S., Savita, Kumar, D., Rath, S., Maitra, A., & Sengupta, S. (2026). Cell death & disease, 10.1038/s41419-026-08846-3. Advance online publication. https://doi.org/10.1038/s41419-026-08846-3
Novel truncating Desmin mutation Arg150Stop disrupts structural integrity and cellular homeostasis by formation of persistent aggregate-like structure.

Mitra S, Ghosh T, Mishra AK, Sanga S, R SG, Maulik M, Acharya M. Cell Death Discov. 2026 Jun 5. doi: 10.1038/s41420-026-03184-x. Epub ahead of print. PMID: 42248875.
Genomic and functional approaches point to potential determinants of neonatal K. pneumoniae sepsis.

Rout M, Rani K, Mahanta J, Majhi S, Sahoo SS, Mallick S, Mohapatra D, Som TK, Mahapatra A, Mohanty S, Raj VS, Mohapatra SK. Microbiol Spectr. 2026 Apr 27:e0411825. doi: 10.1128/spectrum.04118-25. Epub ahead of print. PMID: 42037379.
Partitioning genetic pleiotropy within tissue-specific regulatory patterns.

Panja P, Biswas D, Bhattacharjee S. Cell Genom. 2026 Apr 8;6(4):101212. doi: 10.1016/j.xgen.2026.101212. PMID: 41956071; PMCID: PMC13069840.
Reconstruction of the genetic history of the Austro-Asiatic- and Dravidian-speaking tribal populations of South Asia.

Dey A, Pal M, Nandi D, Basu A. iScience. 2026 Mar 5;29(4):115241. doi: 10.1016/j.isci.2026.115241. PMID: 41952992; PMCID: PMC13053704.
Metabolic gene expression-based stratification and prognostic risk predictive model of head and neck squamous cell carcinoma.

Sau S, Gupta A, Sinha S, Mohiyuddin SMA, Korwar AM. NPJ Syst Biol Appl. 2026 Mar 25. doi: 10.1038/s41540-026-00689-0. Epub ahead of print. PMID: 41881992.
Gut microbiome changes in people with diabetic retinopathy in India. DRMS-India report # 1: operational protocol and trends from first 100 participants.

Takkar B, Maddheshiya A, Adhikary P, Reddy VA, Majumder PP, Mukherjee S, Das T; the DRMS Group. Gut Pathog. 2026 Mar 13;18(1):36. doi: 10.1186/s13099-026-00821-9. PMID: 41827072; PMCID: PMC13097751.
Genebody specific epigenomic reprogramming of transcriptome promotes immune evasion in oropharyngeal cancer patients in North-Eastern India.

Ghosh S, Bagchi I, Marthong L, Patra S, Shunyu NB, Ghosh S, Maitra A. Clin Epigenetics. 2026 Mar 8. doi: 10.1186/s13148-026-02088-y. Epub ahead of print. PMID: 41796351.
K63-linked ubiquitylation of RMI1 by RNF8 is essential to its recruitment to stalled forks.

Arun R, Kumbhakar S, Kaur T, Kaur S, Sengupta S. Cell Mol Life Sci. 2026 Mar 5;83(1):153. doi: 10.1007/s00018-026-06156-7. PMID: 41784835.
Identification of circulating microRNA signature in pancreatic ductal adenocarcinoma and chronic pancreatitis patients from Indian population.

Saha B, Ghosal S, Chakravarty S, Ray S, Saha H, Das K, Manna S, Bandyopadhyay A, De U, Ghosh I, Biswas NK, Goswami S. Gene. 2026 May 5;989:150061. doi: 10.1016/j.gene.2026.150061. Epub 2026 Feb 19. PMID: 41722742.

Research Spotlight

BLM regulates MALT1-driven NF-κB signalling and is targetable in B-cell malignancies.

Agrawal, R., Ghosh, S., Kumar, N., Mukherjee, C., Sharma, V., Arun, R., Deb, R., Sarkar, S., Savita, Kumar, D., Rath, S., Maitra, A., & Sengupta, S. (2026). Cell death & disease, 10.1038/s41419-026-08846-3. Advance online publication. https://doi.org/10.1038/s41419-026-08846-3

Novel truncating Desmin mutation Arg150Stop disrupts structural integrity and cellular homeostasis by formation of persistent aggregate-like structure.

Mitra S, Ghosh T, Mishra AK, Sanga S, R SG, Maulik M, Acharya M. Cell Death Discov. 2026 Jun 5. doi: 10.1038/s41420-026-03184-x. Epub ahead of print. PMID: 42248875.

Genomic and functional approaches point to potential determinants of neonatal K. pneumoniae sepsis.

Rout M, Rani K, Mahanta J, Majhi S, Sahoo SS, Mallick S, Mohapatra D, Som TK, Mahapatra A, Mohanty S, Raj VS, Mohapatra SK. Microbiol Spectr. 2026 Apr 27:e0411825. doi: 10.1128/spectrum.04118-25. Epub ahead of print. PMID: 42037379.

Partitioning genetic pleiotropy within tissue-specific regulatory patterns.

Panja P, Biswas D, Bhattacharjee S. Cell Genom. 2026 Apr 8;6(4):101212. doi: 10.1016/j.xgen.2026.101212. PMID: 41956071; PMCID: PMC13069840.

Reconstruction of the genetic history of the Austro-Asiatic- and Dravidian-speaking tribal populations of South Asia.

Dey A, Pal M, Nandi D, Basu A. iScience. 2026 Mar 5;29(4):115241. doi: 10.1016/j.isci.2026.115241. PMID: 41952992; PMCID: PMC13053704.

Metabolic gene expression-based stratification and prognostic risk predictive model of head and neck squamous cell carcinoma.

Sau S, Gupta A, Sinha S, Mohiyuddin SMA, Korwar AM. NPJ Syst Biol Appl. 2026 Mar 25. doi: 10.1038/s41540-026-00689-0. Epub ahead of print. PMID: 41881992.

Gut microbiome changes in people with diabetic retinopathy in India. DRMS-India report # 1: operational protocol and trends from first 100 participants.

Takkar B, Maddheshiya A, Adhikary P, Reddy VA, Majumder PP, Mukherjee S, Das T; the DRMS Group. Gut Pathog. 2026 Mar 13;18(1):36. doi: 10.1186/s13099-026-00821-9. PMID: 41827072; PMCID: PMC13097751.

Genebody specific epigenomic reprogramming of transcriptome promotes immune evasion in oropharyngeal cancer patients in North-Eastern India.

Ghosh S, Bagchi I, Marthong L, Patra S, Shunyu NB, Ghosh S, Maitra A. Clin Epigenetics. 2026 Mar 8. doi: 10.1186/s13148-026-02088-y. Epub ahead of print. PMID: 41796351.

K63-linked ubiquitylation of RMI1 by RNF8 is essential to its recruitment to stalled forks.

Arun R, Kumbhakar S, Kaur T, Kaur S, Sengupta S. Cell Mol Life Sci. 2026 Mar 5;83(1):153. doi: 10.1007/s00018-026-06156-7. PMID: 41784835.

Identification of circulating microRNA signature in pancreatic ductal adenocarcinoma and chronic pancreatitis patients from Indian population.

Saha B, Ghosal S, Chakravarty S, Ray S, Saha H, Das K, Manna S, Bandyopadhyay A, De U, Ghosh I, Biswas NK, Goswami S. Gene. 2026 May 5;989:150061. doi: 10.1016/j.gene.2026.150061. Epub 2026 Feb 19. PMID: 41722742.