BRIC-NIBMG | BRIC National Institute of Biomedical Genomics

Nuclear-cytoplasmic translocation of MCIDAS couples transcription with massive de novo centriole biogenesis in multiciliated cells.

Lu H, Goh KJ, Tan EK, James CT, Ghosh A, Boudjema AR, Lorenzini PA, Bingle CD, Maurer-Stroh S, Biswas NK, Meunier A, Dunn NR, Roy S. Cell Rep. 2025 Oct 28;44(10):116321. doi: 10.1016/j.celrep.2025.116321. Epub 2025 Sep 19. PMID: 40974574.
Activated protein C promotes human lung cancer progression through the release of tumor extracellular vesicles and transfer of microRNA-200a.

Chatterjee M, Parashar D, Pandey R, Mukherjee T, Gupta S, Paul S, Chatterjee A, Potale G, Dhara P, Uddandrao VVS, Sengottuvelu S, Sharma A, Kumar U, Magisetty J, Maitra A, Das K. Cell Death Dis. 2025 Nov 21;16(1):848. doi: 10.1038/s41419-025-08173-z. PMID: 41271627; PMCID: PMC12638984.
Deciphering mechanisms leading to preterm birth through post-GWAS integration of multi-omics data

Bhattacharjee E, Thiruvengadam R, Varshney D, Das J, Ayushi, Maji R, Mondal P, Ghosh S, Tailor P, GARBH-Ini Study Team, Natchu UCM, Wadhwa N, Kshetrapal P, Bhatnagar S, Maitra A. iScience. Volume 28, Issue 11, 2025, 113861, https://doi.org/10.1016/j.isci.2025.113861
LncRNA CASC19 promotes pancreatic cancer progression by increasing PSPC1 protein stability and facilitating the oncogenic PSPC1/ β-Catenin pathway.

Mukherjee M, Ghosh S, Maity A, Ray S, Saha H, Bahadur RP, Goswami S. Mol Med. 2025 Sep 29;31(1):305. doi: 10.1186/s10020-025-01363-7. PMID: 41023804; PMCID: PMC12482102.
Examining Transcriptomic Markers Associated With Neutrophil Extracellular Traps to Predict Mortality Risk in Neonatal Sepsis.

Shaw D, Santhanam S, Som TK, Bhattacharjee S, Mohapatra SK. Open Forum Infect Dis. 2025 Sep 24;12(9):ofaf570. doi: 10.1093/ofid/ofaf570. PMID: 41001617
JMJD6 and YBX1 physically interact and regulate HOTAIR proximal promoter

Gupta A, Bhardwaj S, Desai KV. Biochem J. 2025 Sep 4;482(17):1289-1305. doi: 10.1042/BCJ20243020. PMID: 40855961.
Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on the Gut Microbiome at Six Months of Age: Findings from the Women and Infants Integrated Growth Study (WINGS) Randomized Controlled Trial

Chowdhury R, Maddheshiya A, Taneja S, Bhandari N, Majumder PP, Strand TA, Pandey RM, Kurpad AV, Mukherjee S. J Nutr. 2025 Jul;155(7):2355-2366. doi: 10.1016/j.tjnut.2025.04.016. PMID: 40615170.
Comprehensive genomic and digital pathology profiling of tobacco-chewer female oral cancer patients simultaneously with integration of single-cell datasets identifies clinically actionable patient subgroups

Ghosh A, Singh S, Mallick TR, Chakravarty S, Varsha Bhagat S, Das C, Gopinath KS, Mohiyuddin A, Maitra A, Majumder PP, Kundu TK, Biswas NK. Clin Transl Med. 2025 Jul;15(7):e70386. doi: 10.1002/ctm2.70386. PMID: 40621643.
Long-term arsenic exposure perturbs gut microbial diversity, composition and predicts metabolic dysregulation

Ghosh S., Nath S., Chakraborty A., Bhowmick S. , Majumdar K.K. , Mukherjee S., Pramanik S.; Journal of Hazardous Materials, 2025, 138836, ISSN 0304-3894, https://doi.org/10.1016/j.jhazmat.2025.138836.
Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients

Mitra P, Saha U, Stephen KJ, Prasad P, Jena S, Patel AK, Bv H, Mondal SK, Kurkalang S, Roy S, Ghosh A, Roy SS, Das Sarma J, Biswas NK, Acharya M, Sharan R, Arun P, Jolly MK, Maitra A, Singh S. J Exp Clin Cancer Res. 2025 May 10;44(1):142. doi: 10.1186/s13046-025-03405-8. PMID: 40349056.

Research Spotlight

Nuclear-cytoplasmic translocation of MCIDAS couples transcription with massive de novo centriole biogenesis in multiciliated cells.

Lu H, Goh KJ, Tan EK, James CT, Ghosh A, Boudjema AR, Lorenzini PA, Bingle CD, Maurer-Stroh S, Biswas NK, Meunier A, Dunn NR, Roy S. Cell Rep. 2025 Oct 28;44(10):116321. doi: 10.1016/j.celrep.2025.116321. Epub 2025 Sep 19. PMID: 40974574.

Activated protein C promotes human lung cancer progression through the release of tumor extracellular vesicles and transfer of microRNA-200a.

Chatterjee M, Parashar D, Pandey R, Mukherjee T, Gupta S, Paul S, Chatterjee A, Potale G, Dhara P, Uddandrao VVS, Sengottuvelu S, Sharma A, Kumar U, Magisetty J, Maitra A, Das K. Cell Death Dis. 2025 Nov 21;16(1):848. doi: 10.1038/s41419-025-08173-z. PMID: 41271627; PMCID: PMC12638984.

Deciphering mechanisms leading to preterm birth through post-GWAS integration of multi-omics data

Bhattacharjee E, Thiruvengadam R, Varshney D, Das J, Ayushi, Maji R, Mondal P, Ghosh S, Tailor P, GARBH-Ini Study Team, Natchu UCM, Wadhwa N, Kshetrapal P, Bhatnagar S, Maitra A. iScience. Volume 28, Issue 11, 2025, 113861, https://doi.org/10.1016/j.isci.2025.113861

LncRNA CASC19 promotes pancreatic cancer progression by increasing PSPC1 protein stability and facilitating the oncogenic PSPC1/ β-Catenin pathway.

Mukherjee M, Ghosh S, Maity A, Ray S, Saha H, Bahadur RP, Goswami S. Mol Med. 2025 Sep 29;31(1):305. doi: 10.1186/s10020-025-01363-7. PMID: 41023804; PMCID: PMC12482102.

Examining Transcriptomic Markers Associated With Neutrophil Extracellular Traps to Predict Mortality Risk in Neonatal Sepsis.

Shaw D, Santhanam S, Som TK, Bhattacharjee S, Mohapatra SK. Open Forum Infect Dis. 2025 Sep 24;12(9):ofaf570. doi: 10.1093/ofid/ofaf570. PMID: 41001617

JMJD6 and YBX1 physically interact and regulate HOTAIR proximal promoter

Gupta A, Bhardwaj S, Desai KV. Biochem J. 2025 Sep 4;482(17):1289-1305. doi: 10.1042/BCJ20243020. PMID: 40855961.

Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on the Gut Microbiome at Six Months of Age: Findings from the Women and Infants Integrated Growth Study (WINGS) Randomized Controlled Trial

Chowdhury R, Maddheshiya A, Taneja S, Bhandari N, Majumder PP, Strand TA, Pandey RM, Kurpad AV, Mukherjee S. J Nutr. 2025 Jul;155(7):2355-2366. doi: 10.1016/j.tjnut.2025.04.016. PMID: 40615170.

Comprehensive genomic and digital pathology profiling of tobacco-chewer female oral cancer patients simultaneously with integration of single-cell datasets identifies clinically actionable patient subgroups

Ghosh A, Singh S, Mallick TR, Chakravarty S, Varsha Bhagat S, Das C, Gopinath KS, Mohiyuddin A, Maitra A, Majumder PP, Kundu TK, Biswas NK. Clin Transl Med. 2025 Jul;15(7):e70386. doi: 10.1002/ctm2.70386. PMID: 40621643.

Long-term arsenic exposure perturbs gut microbial diversity, composition and predicts metabolic dysregulation

Ghosh S., Nath S., Chakraborty A., Bhowmick S. , Majumdar K.K. , Mukherjee S., Pramanik S.; Journal of Hazardous Materials, 2025, 138836, ISSN 0304-3894, https://doi.org/10.1016/j.jhazmat.2025.138836.

Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients

Mitra P, Saha U, Stephen KJ, Prasad P, Jena S, Patel AK, Bv H, Mondal SK, Kurkalang S, Roy S, Ghosh A, Roy SS, Das Sarma J, Biswas NK, Acharya M, Sharan R, Arun P, Jolly MK, Maitra A, Singh S. J Exp Clin Cancer Res. 2025 May 10;44(1):142. doi: 10.1186/s13046-025-03405-8. PMID: 40349056.