Research Spotlight

A genomewide association study on individuals with occludable angles identifies potential risk loci for intraocular pressure / Journal of Genetics 2021

Sudipta Chakraborty, Anshul Sharma, Indranil Bagchi, Soumen Pal, Chandrika Bhattacharyya, Viney Gupta, Arindam Maitra, Samsiddhi Bhattacharjee, Arundhati Sharma, Ramanjit Sihota, Moulinath Acharya PMID: 34608871

Glaucoma is a heterogeneous group of optic neuropathies and is one of the leading causes of irreversible blindness worldwide. Primary angle closure glaucoma (PACG) is a major subtype, prevalent mostly in east and south Asia, where occludable anterior chamber angle is considered as a primary risk factor, which in turn could be responsible for high intraocular pressure (IOP) and subsequent neurodegeneration of retinal ganglion cells. Clinically, IOP is considered as a major risk factor for glaucoma and viewed as an important endophenotype to promote the disease severity. To investigate the comprehensive genomic insights, we conducted a genomewide association study (GWAS) on IOP in individuals with occludable angle (<15 xss=removed P =1.16e-09).>