Research
Research interests:
Understanding the role of genetic and epigenetic changes in modifying disease pathogenesis and response to treatment
Studying the transcriptional regulation of genes in disease context to identify therapeutic targets
Identifying novel genetic variations causing rare genetic diseases
Estimating the prevalence of monogenic disorders and the frequency of the pathogenic alleles associated with the disorder in Indian population
Selected publications:
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Rozenberg JM, Bhattacharya P, Chatterjee R, Glass K, Vinson C. Combinatorial recruitment of CREB, C/EBPb and c-Jun determines activation of promoters upon keratinocyte differentiation. PLoS ONE 8(11): e78179; 2013. doi:10.1371/journal.pone.0078179
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Rishi V*, Bhattacharya P*, Chatterjee R*, Rozenberg J*, Zhao J*, Glass K, Fitzgerald P, and Vinson C. CpG methylation of half-CRE sequences creates C/EBPα binding sites that activate some tissue-specific genes. Proceedings of the National Academy of Sciences of the United States of America, 107: 20311-20316; 2010. (*These authors are considered co-first authors.)
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Bhattacharya P and Sengupta S. Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03. Tissue Antigens, 70: 283-293; 2007. doi: 10.1111/j.1399-0039.2007.00894.x
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Bhattacharya P, Duttagupta C and Sengupta S. Proline homozygosity in codon 72 of p53: A Risk genotype for Human papillomavirus related cervical cancer in Indian women. Cancer Letters, 188: 207-211; 2002. doi.org/10.1016/S0304-3835(02)00430-5
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Bairagya BB, Bhattacharya P, Bhattacharya SK, Dey B, Dey U, Ghosh T, Maiti S, Majumder PP, and et al. Genetic variation and haplotype structures of innate immunity genes in eastern India. Infection, Genetics and Evolution, 8: 360-366; 2008. (Authors are listed in alphabetical order.) doi:10.1016/j.meegid.2008.02.009
Education
1993-1996 BSc with Zoology (Hons.), Calcutta University, Kolkata
1996-1998 MSc in Zoology, Visva Bharati, Santiniketan
1999-2005 PhD (Science), Jadavpur University, Kolkata (work done at India Indian Statistical Institute, Kolkata)
POSITIONS HELD
July 2015 – June 2017
Position Principal Investigator, DST-Women Scientist (WOS-A Scheme)
Institute Division of Cancer Biology & Inflammatory Disorder, CSIR-Indian Institute of Chemical Biology, Kolkata
February 2015 – June 2015
Position Senior Research Associate (CSIR-Scientist’s Pool Scheme)
Institute Division of Cancer Biology & Inflammatory Disorder, CSIR-Indian Institute of Chemical Biology, Kolkata
July 2011 – July 2013
Position Postdoctoral Fellow
Institute Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata
April 2007 – July 2010
Position Postdoctoral Fellow (Exchange Visiting Program)
Institute Gene Regulation Section, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, USA
October 2005 – March 2007
Position Research Associate / Staff
Institute TCG-ISI Centre for Population Genomics, Indian Institute of Molecular Medicine
September 1999- October 2005
Position Research Fellow (JRF/SRF), Ph.D. programme, Indian Statistical Institute
Institute Indian Statistical Institute, Kolkata
2005
Position Visiting Lecturer
Institute Dept. of Biotechnology, Institute of Technology and Marine Engineering, India.
Invited oral presentations in scientific meetings
2005 DBT-NCBS Cancer Brainstorming Workshop, NCBS, Bangalore, India (Invited Speaker)
2010 10th NCI CCR Fellows and Young Investigators Colloquium, PA, USA (Selected speaker)
Invited oral presentations in seminars
2006 Gene Regulation Section, NCI, NIH.
2007 Stanley Group Meeting, NIH, Bethesda, USA.
2009 Department of Microbiology, Bose Institute, Kolkata, India.
2011 Calcutta Consortium for Human Genetics, Dept. of Genetics, Ballygunge Science College, University of Calcutta
2011 Human Genetics Unit, Indian Statistical Institute, Kolkata, India.
Publication
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Rozenberg JM, Bhattacharya P, Chatterjee R, Glass K, Vinson C. Combinatorial recruitment of CREB, C/EBPb and c-Jun determines activation of promoters upon keratinocyte differentiation. PLoS ONE 8(11): e78179; 2013.
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Chatterjee R, Bhattacharya P, Gavrilova O, Glass K, Moitra J, Myakishev M, Pack S, Jou W, Feigenbaum L, Eckhaus M, and Vinson C. Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy. Journal of Molecular Endocrinology, 46: 175-192; 2011.
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Sarkar N, Mondal D, Bhattacharya P, Majumder PP. A novel statistical algorithm for maximizing the utility of HapMap Data to design genetic association studies in non-HapMap populations. International Journal of Data Mining and Bioinformatic, 5 (6): 706-716; 2011.
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Rishi V*, Bhattacharya P*, Chatterjee R*, Rozenberg J*, Zhao J*, Glass K, Fitzgerald P, and Vinson C. CpG methylation of half-CRE sequences creates C/EBP binding sites that activate some tissue-specific genes. Proceedings of the National Academy of Sciences of the United States of America, 107: 20311-20316; 2010. (*These authors are considered co-first authors.)
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Bairagya BB, Bhattacharya P, Bhattacharya SK, Dey B, Dey U, Ghosh T, Maiti S, Majumder PP, and et al. Genetic variation and haplotype structures of innate immunity genes in eastern India. Infection, Genetics and Evolution, 8: 360-366; 2008. (Authors are listed in alphabetical order.)
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Bhattacharya P and Sengupta S. Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03. Tissue Antigens, 70: 283-293; 2007.
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Laikangbam P, Sengupta S, Bhattacharya P, Duttagupta C, Singh Th D, Verma Y, Roy S, Das R and Mukhopadhyay S. A comparative profile of the prevalence and age-distribution of human papillomavirus type 16/18 infections among three states of India with focus on Northeast India. Int J Gynecol Cancer, 17: 107-117; 2007.
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Bhattacharya P, Shankarkumar U and Sengupta S. HLA B*1301 and B*1801 alleles are Positively Associated with HPV Related Cervical Cancer in Women from Kolkata, Eastern India. Int J Hum Genet, 6(2): 139-144; 2006.
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Bhattacharya P and Sengupta S. Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21 jointly mediate cervical cancer susceptibility among Indian women. Gyn Oncol, 99(1): 175-181; 2005.
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Bhattacharya P and Sengupta S. HLA DQB1*03 genotypes and susceptibility to cervical cancer in Indian women. Int J Hum Genet, 5(1): 19-25; 2005.
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Duttagupta C, Sengupta S, Roy M, Sengupta D, Bhattacharya P, Laikangbam P, Roy S and Ghosh S. Are Muslim women less susceptible to oncogenic human papillomavirus infection? : Study from rural eastern India. Int J Gynecol Cancer, 14(2): 293-303; 2004.
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Bhattacharya P, Duttagupta C and Sengupta S. Proline homozygosity in codon 72 of p53: A Risk genotype for Human papillomavirus related cervical cancer in Indian women. Cancer Letters, 188: 207-211; 2002.
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Duttagupta C, Sengupta S, Roy M, Sengupta D, Chakraborty S, Bhattacharya P, Roy S and Ghosh S. Oncogenic HPV infection and uterine cervical cancer: A screening strategy in the perspective of rural India. Eur J Cancer Prev, 11(5): 447-456; 2002.
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Ray M, Sengupta S, Bhattacharya P and Duttagupta C. Human papillomavirus and uterine cervical cancer: State of the art. Science and Culture, 67: 205-211; 2001.
