Research Spotlight

Contrasting Distribution of SARS-CoV-2 Lineages across Multiple Rounds of Pandemic Waves in West Bengal, the Gateway of East and North-East States of India Microbiology Spectrum / July 19, 2022

Animesh K. Singh, Rezwanuzzaman Laskar, Anindita Banerjee, Rajiv Kumar Mondal, Bishal Gupta, Sonia Deb, Shreelekha Dutta, Subrata Patra, Trinath Ghosh, Sumanta Sarkar, Shekhar Ghosh, Sabyasachi Bhattacharya, Debojyoti Roy, Ankita Chakraborty, Meghna Chowdhury, Surajit Mahaptra, Antara Paul, Anup Mazumder, Aparna Chowdhury, Shiv Sekhar Chatterjee, Arunabha Sarkar, Raja Raye, Kuhu Pal, Angshuman Jana, Goutam Barik, Swagata Ganguly, Mitali Chatterjee, Dipankar Majhi, Bhaswati Bandopadhyay, Saumitra Das, Arindam Maitra, Nidhan K. Biswas; DOI:

The evolution of viral variants and their impact on viral transmission have been an area of considerable importance in this pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We analyzed the viral variants in different phases of the pandemic in West Bengal, a state in India that is important geographically, and compared the variants with other states like Delhi, Maharashtra, and Karnataka, located in other regions of the country. We have identified 57 pango-lineages in 3,198 SARS-CoV-2 genomes, alteration in their distribution, as well as contrasting profiles of amino acid mutational dynamics across different waves in different states. The evolving characteristics of Delta (B.1.617.2) sublineages and alterations in hydrophobicity profiles of the viral proteins caused by these mutations were also studied. Additionally, implications of predictive host miRNA binding/unbinding to emerging spike or nucleocapsid mutations were highlighted. Our results throw considerable light on interesting aspects of the viral genomic variation and provide valuable information for improved understanding of wave-defining mutations in unfolding the pandemic.