To develop statistical methods and to innovatively apply statistical methods to the understanding to the genetic basis of human disease. In particular to: (a) robustly identify genomic drivers of oral cancer and obtain deep understanding of the biological underpinnings of oral cancer, with the goal providing precision genomic signatures of prediction and novel therapy; and (b) relate population genomic diversity, in conjunction with family and/or case-control studies, to various facets of common disease, e.g., splitting heritability of a disease to components of common genomic variation, rare genomic variation and environmental factors; response to drugs and vaccines, etc.
Cancer Genomics
India Project Team of the International Cancer Genome Consortium (2013) Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nature Communications 4:2873. [Corresponding Author: MAJUMDER PP]
doi: 10.1038/ncomms3837. Das D, Maitra A, Panda CK, Ghose S, Roy B, Sarin R, MAJUMDER PP (2021) Genes and pathways monotonically dysregulated during progression from normal through leukoplakia to gingivo-buccal oral cancer. npj Genomic Medicine 6: 32; https://doi.org/10.1038/s41525-021-00195-8
Population Genetics and Genomics
Basu A, Mukherjee N, Roy S, Sengupta S, Banerjee S, Chakraborty M, Dey B, Roy M, Roy B, Bhattacharyya NP, Roychoudhury S, MAJUMDER PP (2003) Ethnic India: A genomic view, with special reference to peopling, structure. Genome Research 13: 2277-2290. Basu A, Sarkar-Roy N, MAJUMDER PP (2016) Genomic reconstruction of the history of extant populations of India reveals five distinct ancestral components and a complex structure. Proceedings of the National Academy of Sciences, USA, 113: 1594–1599, doi: 10.1073/pnas.1513197113.
Statistical Methodology
Basu, A., Chaudhuri, P, MAJUMDER PP (2005) Identification of polymorphic motifs using probabilistic search algorithms. Genome Research 15: 67-77.
Gaining a deeper understanding of the relative roles of common and rare variants incommon disease
The emerging picture of common disease genetics is that the majority of heritability is made up of common, largely non-coding variation. However, given our current knowledge of genome biology and the available tools for studying gene function, rare coding variants can make a larger contribution to our biological insight than suggested by the proportion of heritability explained. A set of methods under development have begun to extend these ideas to explore disease biology, by using the full information provided by GWA studies – that is, the genome-wide effect-size vector. In particular, one tests whether a gene set of interest – such as the genes expressed in a particular tissue or cellular process – is relevant to a disease by studying whether it is correlated with the genome-wide effect-size vector. With the ongoing development of a Human Cell Atlas, it should be possible to extend these studies to implicate not just tissues but individual cell types. This will help connect disease-associated genes to specific cell types and mechanisms active in those cell types. I am focusing on this direction of research.
Revising estimates of polygenic risk scores by linking to ancestry-associated genomic spectra
For an individual’s polygenic risk scores of common diseases to have maximal accuracy and precision, it should be derived from data on GWA studies conducted on populations with the appropriate ancestry. A serious issue is that the vast majority of GWA studies has been conducted in European-derived populations, with the consequence that polygenic risk scores currently provide poorer predictors for other groups. It is important that this problem be addressed rapidly. Overcoming this population bias is essential to make polygenic risk scores useful for prediction on individual risks to common diseases. This is another area of my current research.
Integrating multi-omics data to identify perturbations from precancer to cancer and study dynamics of cell-type proportions using oral cancer as an exemplar
In the context of oral cancer, we have been generating multiple types of omics data, from which we identify a different types of variants at the genome-wide scale (that include single nucleotide, copy number, structural and epigenomic) and also dysregulation of gene expression using RNA_sequencing data. This, of course, involves analysis of both tumour and normal tissues. The data of these disparate types need to be integrated, because for example both DNA variants and gene-promoter variants can affect gene expression. Recently, we have carried out an integrative analysis of epigenomic and transcriptomic data to deduce that immunotherapy may be effective in the treatment of oral cancer. I wish to continue work in this direction using similar methodologies to gain robust insights into the process of carcinogenesis.
November 1, 2016 - present |
Distinguished Professor
National Institute of Biomedical Genomics, Kalyani
|
June 9, 2018 - Present |
Emeritus Professor
Indian Statistical Institute, Kolkata |
March 4,2010 – Sept 30,2016 |
Director (Founding Director)
National Institute of Biomedical Genomics, Kalyani |
May 7,2004 - Sept. 30,2017 |
Professor and Head (May7, 2004-March 3, 2010)
Human Genetics Unit
Indian Statistical Institute, Calcutta
|
September 29,2016 - Present |
Adjunct Professor Translational Health Science and Technology Institute, Faridabad |
12/2009- 2015 |
Professor Indian Institute of Science Education & Research, Kolkata |
12/2007-11/2014 |
Honorary Professor Jawaharlal Nehru Centre for Advanced Scientific Research Bangalore |
June 1, 1991 - May 6, 2004 |
Professor & Head (from October 5, 1999 to May 6, 2004)
Anthropology & Human Genetics Unit,
Indian Statistical Institute, Calcutta
|
2001 – 2011 |
Honorary Director
TCG-ISI Centre for Population Genomics, Calcutta
|
June 1, 1987 to May 31, 1991 |
Associate Professor
Anthropology & Human Genetics Unit,
Indian Statistical Institute, Calcutta
|
1990 - 1996 |
Genetics Consultant
Center for Education & Drug Abuse Research,
Western Psychiatric Institute & Clinic,
University of Pittsburgh, U.S.A.
|
1987 - 1989 |
Visiting Assistant Professor of Human Genetics and Biostatistics
Department of Biostatistics, University of Pittsburgh,U.S.A.
|
July 29, 1983 to to May 31, 1987 |
Lecturer
Indian Statistical Institute, Calcutta
|
1982 - 1983 |
Research Instructor
Center for Demographic & Population Genetics, University of Texas,
Houston, U.S.A.
|
1980 - 1982 |
Senior Research Associate
Center for Demographic & Population Genetics,
University of Texas,
Houston, U.S.A.
|
Doctor of Philosophy (Statistics). 1982. Indian Statistical Institute, Calcutta, India.
Master of Statistics. 1975. Indian Statistical Institute, Calcutta, India. (Specialization: Applied Statistics & Data Analysis).
Bachelor of Statistics (Honours). 1974. Indian Statistical Institute, Calcutta, India.
Mahendra Lal Sircar Memorial Endowment Lecture, Indian Association for the Cultivation of Science, 14th December 2018.
‘Meet the Scientist’ Lecture, West Bengal State Student-Youth Science Fair, 30th January 2018, Netaji Indoor Stadium, Kolkata.
Foundation Day Lecture of the Inter-University Centre for Astronomy and Astrophysics, 28th December 2017, Pune. [https://www.youtube.com/user/IUCAASciPOP/live]
Rajasekhara Reddy Endowment Lecture of the Operational Research Society of India, 23rd December 2017, Kolkata.
Presidency University Bicentenary Celebrations Lecture “The Walls of Classrooms are Developing Cracks: The Future Appears Bright.” 9th January 2017, Kolkata. [https://www.youtube.com/watch?v=eQ7SDbgnnBw]
Air Vice Marshal V. Krishnaswamy Memorial Oration, Madhuram Narayanan Centre for Exceptional Children, Chennai, 17th November 2016.
Sudhindranath Mukherjee Memorial Oration, Indian Association of Cancer Research, 16 June 2016.
B. Ramamurthy Memorial Lecture, National Brain Research Centre, Manesar, 29 January 2016.
D.M. Bose Memorial Lecture, Bose Institute, Kolkata, 26 November 2015.
Igniting Innovations in Young Minds Lecture, Pulmocon-2015, Institute of Pulmocare & Research, Kolkata, 10 October 2015.
Foundation Day Lecture, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 18 November 2014
Public Lecture, Indian Institute of Science Education & Research, Mohali, 29 October 2014
Centenary Lecture, School of Tropical Medicine, 27 March 2014
Golden Jubilee Lecture, Pandit Ravishankar Shukla University, Raipur, 27 December 2013.
First D.K. Sen Memorial Lecture, Indian Anthropological Society, Kolkata, September 13, 2013.
20th Foundation Day Oration, Society for Advancement of Human Development & Research, Kolkata, July 21, 2013,
First Aloke K. Ghosh Memorial Lecture, Department of Anthropology, University of Calcutta, June 5, 2013.
B. Mukherji Oration, Indian Pharmacological Society, Kolkata, February 23, 2013
Third Dr. Basu Kumar Bagchi Memorial Lecture, Geeta Palace, Shantipur, West Bengal, January 14, 2013.
Golden Jubilee Lecture of the Indian International Centre, New Delhi. December 1, 2012.
[http://www.iicdelhi.in/webcasts/play_webcast/unity-and-diversity-of-indi...
B.N. Chopra Memorial Lecture, School of Tropical Medicine, Kolkata, February 24, 2012.
First Foundation Day Plenary Lecture, Centre for Cellular and Molecular Platforms, Bangalore, November 18, 2011
Prasanta Chandra Mahalanobis Memorial Lecture, Department of Science & Technology, Government of West Bengal, February 28, 2011
J.C. Ray Oration, Indian Institute of Chemical Biology, April 2, 2011.
L.D. Sanghvi Oration Award, Indian Society of Human Genetics, February 16, 2011.
West Bengal Academy of Science & Technology Annual Oration, December 27, 2010
Professor S.K. Bhattachaya Oration Award, Indian Society of Medical Statistics, November 2010.
Golden Jubilee Lectures, Indian Institute of Technology, Kanpur, 12-13 April 2010
Professor S.P. Ray-Chaudhuri Memorial Lecture, S.P. Ray-Chaudhuri Foundation, Benaras Hindu University, 2 March 2009.
Dr. Gour Gopal Das Memorial Oration of the Indian Physical Society, 28 March 2008, Bose Institute, Kolkata.
India Foundation Day Lecture, 20 February 2008, “The Indian Identity in Science”, Kolkata.
Foundation Day Oration, 11 February 2008, Institute of Life Sciences, Bhubaneswar.
V. Ramalingaswami Memorial Lecture, 30 July 2007, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore.
The 3rd Jyotirmoy Das Memorial Lecture, 2006, XXIX All India Cell Biology Conference, Lucknow.
National Science Day Lecture, 28 February 2006, National Chemical Laboratory (CSIR), Pune.
The 8th Manasi Ram Memorial Lecture, 23 November 2005, Miranda House, University of Delhi.
The 2nd C.C. Li Memorial Lecture of the University of Pittsburgh, entitled “Our Footprints in the Sands of Time: A Statistical-Genetic Traceback”, 29 April 2005, Pittsburgh, U.S.A.
Dimensions of Science Lecture entitled “Tribes, Castes and Genes”, India International Centre, New Delhi, 16 July 2004.
Shri J.N. Bose Memorial Oration entitled “Genetics and the Practice of Medicine – Great Expectations”, R.G. Kar Medical College & Hospital’s Foundation Day, 5 July 2004, Kolkata.
Institute Lecture – 2003, Indian Institute of Technology, Kanpur.
UNESCO Lecture in celebration of the 10th Anniversary of the IBC and the 50th Anniversary of the Discovery of DNA Structure entitled “Our Place in the Genomic Universe”, 14 May 2003, Paris.
Bireswar Chakraborty Memorial Oration – 2003, L.V. Prasad Eye Institute, Hyderabad
CSIR Foundation Day Lecture - 2001, Institute of Microbial Technology, Chandigarh.
U.S. National Institutes of Health “Stigma & Global Health” Lecture, 6 September 2001, Washington D.C.
NCBS-CSCS ‘Through the Lens of Life Sciences’ Public Lecture entitled 'Human Footprints in the Sands of Time: A Genetic Reconstruction with Special Reference to India'. Bangalore, 20 April 2001
Foundation Day Lecture - 2000, National Institute of Immunology, New Delhi.
Foundation Day Lecture - 2000, Centre for Archaeological Studies & Training (Eastern India), Calcutta.
Platinum Jubilee Lecture, Anthropology & Archaeology Section, Indian Science Congress, 2000, Pune, entitled Anthropology and Genomics: The Landscape of this Interface.
Special Lecture, Sixty-sixth mid-year Meeting of the Indian Academy of Sciences, Bangalore
Lt. Col. Upendranath Mukerjee Oration 1999 of the Federation Hall Society, Calcutta, entitled Human Genome Studies: Some Ethical Issues and Dilemmas.
Platinum Jubilee Lecture, Statistics Section, Indian Science Congress, 1998, Hyderabad, entitled Some Statistical Methods and Applications in Human Genetics.
On June 24, 2017, Professor Partha Majumder has participated in a hour-long discussion on “The Kith and Kin” (#TKAK) with Professor Raghavendra Gadagkar of IISc and Professor Deepak Mehta of Shiv Nader University. The discussion is available for free-listening on
https://syntalk.wordpress.com/episodes/turn-three/tkak/ (website link)
https://goo.gl/BkxaBH (short link, SoundCloud).
Genes and Probabilities : https://www.youtube.com/watch?v=oiDbzevzQdE
Infectious Disease – Tuberculosis: https://www.youtube.com/watch?v=2mxkGDMgZzM
Eureka: https://www.youtube.com/watch?v=2mxkGDMgZzM
An Overview of Our Second Genome: https://www.youtube.com/watch?v=jN5IPBB5P6o
Mint Interview: https://www.youtube.com/watch?v=s-s5pTNbWLE
Editorial Boards
Genome Biology and Evolution (2014-2017)
Human Genetics (2013-2015)
BMC Genetics (2012- )
Journal of Biosciences (2012- )
Annals of Human Genetics [London] (2008-2013)
Genome Research [Cold Spring Harbor Laboratory,USA] (2008-2012 )
Sankhya - The Indian Journal of Statistics [Calcutta] (2000-2002)
Genetic Epidemiology [International Genetic Epidemiology Society, USA] (1997-2001)
Human Biology [USA] (1995 - 1997)
Journal of Human Ecology [India] (1994 - 2004)
Indian Journal of Human Genetics [Indian Society of Human Genetics] (1995 - 2015)
Journal of Genetics (1996 - )
Annals of Human Biology [U.K.] (2001-2007)
Anthropological Science [Japan] (2000- )
Journal of Biosciences [Indian Academy of Sciences] (2006- )
Resonance [Indian Academy of Sciences] (1995 -1996)
Service to National Organizations
Rendered service to the Office of the Principal Scientific Adviser to the Government of India, Indian National Science Academy, various agencies of the Government of India, particularly Department of Biotechnology, Department of Science & Technology, Indian Council of Medical Research, Indian Council of Agricultural Research and Council of Scientific & Industrial Research and to various Universities and Institutes, as member of Task Forces, Monitoring Committees and Review Boards, Scientific Advisory Committes, and Committees for the promotion of international co-operation in science.
Service to International Organizations
Engaged in teaching courses at various levels (undergraduate and graduate) at the Indian Statistical Institute, University of Texas, University of Pittsburgh, Calcutta University and elsewhere, for over three decades. Taught a wide range of courses, including Basic Statistical Methods, Probability, Multivariate Analysis, Epidemiology, Computer Programming, Human Genetics, Statistical Methods in Genetics, etc.
Five students have received their Ph.D. degrees on human and statistical genetics: (1) Swapan K. Nath [presently a faculty member of the Oklahoma Medical Research Foundation]; (2) Saurabh Ghosh [presently a faculty member of the Indian Statistical Institute, Kolkata], (3) Analabha Basu [presently a Fellow of the National Institute of Biomedical Genomics, Kolkata], (4) Samir K. Sil [presently a faculty member of the Tripura University, Agartala], and (5) Sanjukta Mallik [has just been awarded the PhD degree; looking for a position]. Currently, supervising the work of four Ph.D. students.
Past Funding: Received research funding from the American Heart Association; Department of Biotechnology, Govt. of India; Indian Council of Medical Research; and, National Institutes of Health, USA. Successfully completed over 20 extramurally-funded research and training projects.
Current Funding:
Organized the International Conference on Human Population Genetics (in Celebration of the Birth Centenary of J.B.S. Haldane), Calcutta, 1992.
Organized training and hands-on workshops on human genetics on a sustained, nearly annual, basis, since 1996. The first workshop was funded by the Department of Biotechnology, Government of India; subsequent workshops have been funded by the Fogarty International Center, National Institutes of Health, USA. Over the years, more than 500 research fellows and junior faculty members have been trained in these workshops.
Organized conferences on human genetics on behalf of the Human Genome Organisaton.
Established a private-public partnership institution on human genetics in 2001, called the TCG-ISI Centre for Population Genomics. This not-for-profit, DSIR recognized, institution is a collaboration between The Chatterjee Group and the Indian Statistical Institute, and has been conducting human genomic research funded by ICMR, DBT and the NIH, USA.