National Institute Of Biomedical Genomics (NIBMG) National Institute Of Biomedical Genomics National Institute Of Biomedical Genomics

Name Sharmila Sengupta

Email :ssg1

Position Professor : National Institute of Biomedical Genomics (NIBMG) , Kalyani, West Bengal, India October 2010 till date.

Highest Educational Qualification Ph.D.

Past Appointments

 

•  Associate Professor: Human Genetics Unit, Indian Statistical Institute, Kolkata ( 2007-2010)

•  Assistant Professor: Human Genetics Unit, Indian Statistical Institute, Kolkata ( 2003-2007 )

•  Senior Lecturer: Human Genetics Unit, Indian Statistical Institute, Kolkata ( 2000-2003 )

•  Lecturer: Biochemistry Unit, Indian Statistical Institute, Kolkata ( 1995-2003)

 

  Awards & Honours

•  Received the Overseas Research Associateship Award of the Department of Biotechnology (DBT, Govt. of India) for the year 2000- 2001 and worked on a project entitled "Molecular mechanisms of HPV related cervical neoplasia" under the supervision of Professor Saleem A Khan, at the Department of Molecular Genetics and Biochemistry of the University of Pittsburgh, School of Medicine, USA. ( November 2001- February 2002 ).

 

Fellowships & Memberships of Professional Societies

  • Life Member of the Environmental Mutagen Society of India, 1991
  • Member of the International Society for Preventive Oncology, 2004.
  • Life Member of the Indian Association of Cancer Research, 2005
  • Life Member of Asia Oceania Research Organization on Genital Infection and Neoplasia (AOGIN), 2009
  • Life Member and Member of the Executive Committee of Calcutta Consortium on Human Genetics, 2009

Orations & Special Lectures

•  "Prevalence of high risk HPV16/18 infection in cervical neoplasia, " at the workshop entitled "Uterine cervical cancer: database, statistical modelling and other issues" during March 23-24, 2000, a joint collaboration of Biochemistry Unit and Statistics and Mathematics Unit of the Indian Statistical Institute, Kolkata

  •  " Human papillomavirus infection and the role of host genetic factors in cervical cancer: some aspects of the disease in Eastern India " at the University Grants Commission Sponsored Refresher Course on "Trends in Drugs and Pharmaceuticals", September 10-30, 2002 at the Department of Pharmaceutical Technology, Jadavpur University, Kolkata.

•  "Involvement of host genetic factors in the pathogenesis of HPV related cervical cancer in Indian women " at the International Agency for Research on Cancer, Lyon, France on February 10, 2004 and at Johannes-Guttenburg University (Institute for Medicine, Biometry and Bioinformatics), Mainz, Germany on February 18, 2004.

•  " Human papillomavirus infection and cervical cancer in Indian women . " at the Cancer Centre and Welfare Home & Research Institute, Thakurpukur, Kolkata, on May 27, 2004 at the CME of Department of Gynaecology and Obstetrics.

•  "High risk human papillomavirus infection and cervical cancer ", at the Department of Biophysics, Molecular Biology and Genetics, Calcutta University, as a part of the course on "Genetic Pathology" offered to Medical and Scientific personnel seeking a career in Medical Diagnostics, 2004-2006.

•  "The prevalence of high-risk human papillomavirus infection among normal women from various Indian populations " at a regional workshop on "Women, Work and Health" on 16 th June 2004, organized jointly by Women's Sahayog and Stree Shakti as a part of the International Congress on Women, Work and Health held in New Delhi in November 2005; venue: Indian Institute of Social Welfare and Business Management, Kolkata.

•  " Human papillomavirus related cervical cancer: some genetic risk factors of disease ", at the Second Workshop on Genetic Epidemiological Methods for Dissection of Complex Human Traits, December 13-21, 2004, Kolkata; jointly organized by TCG-ISI Centre for Population Genomics, Kolkata and University of Pittsburgh, Pittsburgh, USA.

•  "Predisposition to HPV16/18 infections and cervical cancer: some insights from analysis of host genetic factors" , XXXII Annual Conference of Indian Society of Human Genetics and International Symposium on "Deconstructing Human Diseases: The Genomic Advantage", February 14 -16, 2007, organized by Indian Institute of Chemical Biology, Kolkata, India.

•  " HPV prevalence patterns within general populations in India: some clues towards developing prospective prophylactic vaccines ". International Conference on Emerging and Re-Emerging Viral Diseases of the Tropics and Sub-Tropics, New Delhi, India, 11 - 14 December, 2007. - New Delhi: Indian Virological Society Annual Meeting

•  "Genetic and epigenetic factors associated with oncogenicity of HPV16 among Indian women", International Symposium on Human Papillomavirus associated Cancers: Translating Research into Cancer Prevention and Medicine. November 1-3, 2008, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.

•  " HPV prevalence patterns within general populations in India: some clues towards developing prospective prophylactic vaccines ". Biennial Conference (Interim) of Asia Oceania Research Organization on Genital Infection and Neoplasia (AOGIN) on Freedom from Cervical Cancer, April 25-26, 2009, organized by Chittaranjan National Cancer Institute, Kolkata, India.

•  "Novel molecular mechanisms of HPV16 related cervical carcinogenesis ", 4th Biennial Conference of Asia Oceania Research Organization on Genital Infection and Neoplasia (AOGIN) on Towards Eradication of Cervical Cancer, March 26-28, 2010, organized by All India Institute of Medical Sciences, New Delhi, India.

•  "Some Aspects of host virus interactions in HPV related cervical cancer pathogenesis ", New Frontiers in Haematology and Oncology, September 11-12, 2010,Organized by Netaji Subhash Chandra Bose Cancer Research Institute September, 2010

 

Research Interests

•  Natural history of HPV infection and cervical cancer development among Indian women

•  Exploring host genetic (genomics based approach) and epigenetic factors (methylation profiling based) that may influence cervical cancer pathogenesis

•  Exploring viral (HPV16 and 18) factors such as genetic, epigenetic changes, viral physical status (episomal or integrated) and viral load, that may influence cervical cancer pathogenesis

•  Development of biomarkers for efficient diagnosis and predicting the prognosis of cervical cancer based on genomics/transcriptome analysis (mRNA and non-coding RNAs)/proteomics of various pathological stages of cervical cancer in consideration of viral mRNA profiles

•  Immunogenicity testing of HPV16 in relation to genetic variations to draw insights for vaccine development

 

Current Projects

•  Host-virus interactions at the genetic and epigenetic levels in HPV related cervical cancer in Indian women (Department of Biotechnology, Govt. of India; ongoing).

•  Understanding the natural history of HPV infection and cervical cancer development among Indian women

•  Variation in human gene expression among women Indian women: genomic correlates, gene regulation and impact on HPV16 related cervical cancer pathogenesis

 

Past Major Projects

•  Human uterine cervix cancer database: Molecular Epidemiology (intramural funding; Indian Statistical Institute; 1999-2002)

•  HPV Infection and Cervical cancer in the Northeastern States of Sikkim and Manipur (intramural funding; Indian Statistical Institute; 2000-2003)

•  Uterine cervical cancer prevention: A low cost screening program in West Bengal (Grant: Department of Science and Technology, West Bengal; 2001-2003)

•  Feasibility of a screening program with abnormal cytology and oncogenic human papillomavirus and other infections in the Maria-Gond tribal women: reproductive Health Care Study (Indian Council of Medical Research; 2004-2005)

•  Cervical Neoplasia: Host genetic factors for high- risk HPV infection and its natural history (intramural funding; Indian Statistical Institute; 2002-2005)

•  Genetic and epigenetic changes associated with epithelial cell transformation and invasion(intramural funding; Indian Statistical Institute; 2005-2008)

•  Chronic exposure to environmental toxins and the risk to human health (The Ministry of Environment and Forests, Govt. of India; 2006-2009).

 

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NATIONAL INSTITUTE OF BIOMEDICAL GENOMICS, Netaji Subhas Sanatorium (T.B. Hospital), 2nd Floor P.O.: N.S.S., Kalyani 741251, West-Bengal, INDIA